Enhanced Efficacy of Sirolimus-Eluting Bioabsorbable Magnesium Alloy Stents in the Prevention of Restenosis

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	Enhanced Efficacy of Sirolimus-Eluting Bioabsorbable Magnesium Alloy Stents in the Prevention of Restenosis
	H. W. Li; H. S. Zhong; K. Xu; K. Yang; J. Liu; B. C. Zhang; F. Zheng; Y. H. Xia; L. L. Tan; D. O. Hong
	2011
发表期刊	Journal of Endovascular Therapy
ISSN	1526-6028
卷号	18 期号:3 页码:407-415
摘要	Purpose: To determine the efficacy of sirolimus-eluting bioabsorbable magnesium alloy stents (SEBMAS) in restenosis prevention. Methods: A balloon-expandable bioabsorbable magnesium alloy stent (BMAS) was created and coated with biodegradable poly(lactic acid-co-trimethylene carbonate) that contained the antiproliferative drug sirolimus (140 +/- 40 mu g/cm(2)). Both the uncoated BMAS and the coated SEBMAS were deployed 2 cm apart in balloon-injured infrarenal abdominal aortas of 20 New Zealand white rabbits. The stented aortic segments were removed at 30, 60, 90, and 120 days (5 rabbits per interval) after implantation. The average stent strut sectional area of each group was measured to evaluate the degree of magnesium corrosion and to forecast the biodegradation time profile of the magnesium stent. Histology and histopathology of the sectioned stented aortic segments were performed to evaluate neointima formation, endothelialization, and inflammation. Results: The SEBMAS degraded gradually after being implanted into the rabbit aorta, and total biocorrosion occurred after similar to 120 days. In all groups, the lumen area was significantly greater, but the neointimal area was significantly smaller in SEBMAS segments compared with the uncoated BMAS segments (p<0.05) at all time points. There was no significant difference in the injury or inflammation scores between the groups. Endothelialization was delayed at 30 days in the SEBMAS segments vs. the uncoated BMAS segments. Conclusion: SEBMAS further reduces intimal hyperplasia and improves the lumen area when compared to uncoated BMAS; however, it delays vascular healing and endothelialization. J Endovasc Ther. 2011; 18: 407-415
部门归属	[li, haiwei; zhong, hongshan; xu, ke; liu, jing; xia, yonghui; hong, duo] china med univ, dept radiol, affiliated hosp 1, key lab diagnost imaging & int radiol, shenyang 110001, liaoning prov, peoples r china. [yang, ke; zhang, bingchun; zheng, feng; tan, lili] chinese acad sci, inst met res, shenyang, peoples r china.;xu, k (reprint author), china med univ, dept radiol, affiliated hosp 1, key lab diagnost imaging & int radiol, shenyang 110001, liaoning prov, peoples r china;kexu@vip.sina.com
关键词	Bioabsorbable Stent Balloon-expandable Stent Sirolimus-eluting Stent Neointimal Hyperplasia Restenosis Porcine Coronary-arteries Metal Stents Bare-metal Implantation Paclitaxel Safety Registry
URL	查看原文
WOS记录号	WOS:000291728200025
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/30466
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	H. W. Li,H. S. Zhong,K. Xu,et al. Enhanced Efficacy of Sirolimus-Eluting Bioabsorbable Magnesium Alloy Stents in the Prevention of Restenosis[J]. Journal of Endovascular Therapy,2011,18(3):407-415.
APA	H. W. Li.,H. S. Zhong.,K. Xu.,K. Yang.,J. Liu.,...&D. O. Hong.(2011).Enhanced Efficacy of Sirolimus-Eluting Bioabsorbable Magnesium Alloy Stents in the Prevention of Restenosis.Journal of Endovascular Therapy,18(3),407-415.
MLA	H. W. Li,et al."Enhanced Efficacy of Sirolimus-Eluting Bioabsorbable Magnesium Alloy Stents in the Prevention of Restenosis".Journal of Endovascular Therapy 18.3(2011):407-415.