Finite element analyses for design evaluation of biodegradable magnesium alloy stents in arterial vessels

IMR OpenIR

	Finite element analyses for design evaluation of biodegradable magnesium alloy stents in arterial vessels
	W. Wu; D. Gastaldi; K. Yang; L. L. Tan; L. Petrini; F. Migliavacca
	2011
发表期刊	Materials Science and Engineering B-Advanced Functional Solid-State Materials
ISSN	0921-5107
卷号	176 期号:20 页码:1733-1740
摘要	Biodegradable magnesium alloy stents (MAS) can provide a great benefit for diseased vessels and avoid the long-term incompatible interactions between vessels and permanent stent platforms. However, the existing MAS showed insufficient scaffolding to the target vessels due to short degradation time. In this study, a three dimensional finite element model combined with a degradable material model of AZ31 (Al 0.03, Zn 0.01, Mn 0.002 and Mg balance, mass percentage) was applied to three different MAS designs including an already implanted stent (Stent A), an optimized design (Stent B) and a patented stent design (Stent C). One ring of each design was implanted through a simulation in a vessel model then degraded with the changing interaction between outer stent surface and the vessel. Results showed that a proper stent design (Stent B) can lead to an increase of nearly 120% in half normalized recoil time of the vessel compared to the Stent A; moreover, the expectation that the MAS design, with more mass and optimized mechanical properties, can increase scaffolding time was verified numerically. The Stent C has more materials than Stent B; however, it only increased the half normalized recoil time of the vessel by nearly 50% compared to the Stent A because of much higher stress concentration than that of Stent B. The 3D model can provide a convenient design and testing tool for novel magnesium alloy stents. (C) 2011 Elsevier B.V. All rights reserved.
部门归属	[wu, wei; gastaldi, dario; petrini, lorenza; migliavacca, francesco] politecn milan, dept struct engn, lab biol struct mech, i-20133 milan, italy. [yang, ke; tan, lili] chinese acad sci, inst met res, div specialized mat & devices, shenyang, peoples r china.;gastaldi, d (reprint author), politecn milan, dept struct engn, lab biol struct mech, piazza leonardo da vinci 32, i-20133 milan, italy;dario.gastaldi@polimi.it
关键词	Stent Finite Element Degradable Materials Continuum Damage Mechanics Corrosion Stress-corrosion Cracking Coronary-artery Flexibility Fatigue
URL	查看原文
WOS记录号	WOS:000297877300018
引用统计	被引频次：71[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/30777
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	W. Wu,D. Gastaldi,K. Yang,et al. Finite element analyses for design evaluation of biodegradable magnesium alloy stents in arterial vessels[J]. Materials Science and Engineering B-Advanced Functional Solid-State Materials,2011,176(20):1733-1740.
APA	W. Wu,D. Gastaldi,K. Yang,L. L. Tan,L. Petrini,&F. Migliavacca.(2011).Finite element analyses for design evaluation of biodegradable magnesium alloy stents in arterial vessels.Materials Science and Engineering B-Advanced Functional Solid-State Materials,176(20),1733-1740.
MLA	W. Wu,et al."Finite element analyses for design evaluation of biodegradable magnesium alloy stents in arterial vessels".Materials Science and Engineering B-Advanced Functional Solid-State Materials 176.20(2011):1733-1740.