Potential antiosteoporosis effect of biodegradable magnesium implanted in STZ-induced diabetic rats

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	Potential antiosteoporosis effect of biodegradable magnesium implanted in STZ-induced diabetic rats
	W. L. Yang; Y. Zhang; J. H. Yang; L. L. Tan; K. Yang
	2011
发表期刊	Journal of Biomedical Materials Research Part A
ISSN	1549-3296
卷号	99A 期号:3 页码:386-394
摘要	Pure magnesium (Mg) was implanted intramedullary into the femur of streptozotocin (STZ)-induced diabetic rats to investigate its effect on bone growth after 6 weeks degradation. The experimental results showed that the femoral BMD in diabetic rats was significantly lower than that in controls (p < 0.01) but restored notably by Mg implantation. The contents of calcium (Ca), phosphorus (P), Mg, zinc (Zn), potassium (K), strontium (Sr), and sulfur (S) in bone of diabetic group were significantly lower than those in controls but remarkably increased with implantation of Mg. The residual weight calculation showed that 29.41% of Mg was degraded in vivo. The energy dispersive X-ray spectroscopy (EDS) analysis showed that the reaction layer on the surface of the Mg implant mainly consisted of C, Ca, O, P, and Mg. Besides, serum Mg level was significantly decreased in diabetic group compared with the control group but increased by Mg treatment. Also, there were no significant differences in body weight and blood glucose, as well as blood glycosylated hemoglobin (HbAIc%), serum Ca, alanine aminitransperase (ALT), aspartate aminotransferase (AST), uric acid (UA), nonesterified fatty acid (NEFA), cholinesterase (CHE), and creatinine (CR) levels between diabetic and Mg-implanted rats. The study indicated that Mg implant had no obvious toxicity in STZ-induced diabetic rats and may act as a potential agent to treat osteoporosis. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 99A: 386-394, 2011.
部门归属	[yang, weili; zhang, yu; yang, jianhong] chinese acad sci, grad univ, coll life sci, beijing 100049, peoples r china. [tan, lili; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china.;yang, jh (reprint author), chinese acad sci, grad univ, coll life sci, 19a yuquan rd, beijing 100049, peoples r china;yangjh@gucas.ac.cn
关键词	Pure Magnesium Implant Osteoporosis Bmd Diabetic Rat In-vivo Corrosion To-ultratrace Elements Dietary Magnesium Multielement Determination Bone Mass Calcium Osteoporosis Alloys Phosphorus Deficiency
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WOS记录号	WOS:000296608900007
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/30833
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	W. L. Yang,Y. Zhang,J. H. Yang,et al. Potential antiosteoporosis effect of biodegradable magnesium implanted in STZ-induced diabetic rats[J]. Journal of Biomedical Materials Research Part A,2011,99A(3):386-394.
APA	W. L. Yang,Y. Zhang,J. H. Yang,L. L. Tan,&K. Yang.(2011).Potential antiosteoporosis effect of biodegradable magnesium implanted in STZ-induced diabetic rats.Journal of Biomedical Materials Research Part A,99A(3),386-394.
MLA	W. L. Yang,et al."Potential antiosteoporosis effect of biodegradable magnesium implanted in STZ-induced diabetic rats".Journal of Biomedical Materials Research Part A 99A.3(2011):386-394.