| Effects of Ti2448 half-pin with low elastic modulus on pin loosening in unilateral external fixation | |
| K. Zheng; X. K. Li; J. Fu; X. L. Fan; P. Wang; Y. L. Hao; S. J. Li; H. B. Fan; Z. Guo | |
| 2011 | |
| Source Publication | Journal of Materials Science-Materials in Medicine
 |
| ISSN | 0957-4530 |
| Volume | 22Issue:6Pages:1579-1588 |
| Abstract | The objective of this study was to compare the benefits of titanium 2448 (Ti2448) half-pin and titanium-6 aluminium-4 vanadium (TAV) half-pin on reducing pin loosening during external fracture fixation. Although having similar strength, Ti2448 half-pin had even lower elastic modules(33 GPa) when compared with TAV half-pin (110 GPa), which was similar to that of cortical bone (20 GPa). In the external fixation of tibial model fractures and canine cadaveric tibia fractures, Ti2448 half-pin had greater recoverable deformation and less stress concentration at the pin-bone interface in compression, torsion, and four-points bending test. Then, tibial fractures were created in 24 dogs and stabilized with four half-pins of either Ti2448 or TAV in each animal. At 4 and 8 weeks post-operatively, fracture healing and pin loosening was assessed by radiographic grading scale. The scores of Ti2448 group were significantly higher than those of TAV group. Micro-CT analysis also indicated larger quantity and higher quality of newly formed bone at pin-bone interface in Ti2448 group. Histology observation showed the newly formed bone integrated well into the threads of Ti2448 half-pins. In contrast, there was a layer of necrotic tissue between the bone tissue and TAV half-pin at pin-bone interface in TAV group. The extraction torque values of Ti2448 half-pins near the fracture line were significantly higher than those TAV pins. In conclusion, the Ti2448 half-pin with low elastic modulus could enhance osseointegration and reduce pin loosening when compared with TAV half-pin. It is a promising biomaterial for constructing external fixation system in clinical application. |
| description.department | [zheng, kai; li, xiaokang; fu, jun; fan, xiangli; wang, pan; guo, zheng] fourth mil med univ, xi jing hosp, dept orthoped oncol, xian 710032, peoples r china. [fan, hongbin] fourth mil med univ, xi jing hosp, dept orthoped surg, xian 710032, peoples r china. [hao, yulin; li, shujun] chinese acad sci, shenyang natl lab mat sci, inst met res, shenyang 110016, peoples r china.;fan, hb (reprint author), fourth mil med univ, xi jing hosp, dept orthoped oncol, xian 710032, peoples r china;fanhb@fmmu.edu.cn guozheng@fmmu.edu.cn |
| Keyword | Skeletal Fixation Stainless-steel Tract Infection Schanz Screws Bone Complications Strength Fractures Interface Movement |
| URL | 查看原文 |
| WOS ID | WOS:000291702500021 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/30963 |
| Collection | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | K. Zheng,X. K. Li,J. Fu,et al. Effects of Ti2448 half-pin with low elastic modulus on pin loosening in unilateral external fixation[J]. Journal of Materials Science-Materials in Medicine,2011,22(6):1579-1588. |
| APA | K. Zheng.,X. K. Li.,J. Fu.,X. L. Fan.,P. Wang.,...&Z. Guo.(2011).Effects of Ti2448 half-pin with low elastic modulus on pin loosening in unilateral external fixation.Journal of Materials Science-Materials in Medicine,22(6),1579-1588. |
| MLA | K. Zheng,et al."Effects of Ti2448 half-pin with low elastic modulus on pin loosening in unilateral external fixation".Journal of Materials Science-Materials in Medicine 22.6(2011):1579-1588. |
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