Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial

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	Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial
	E. L. Zhang; H. Y. Chen; F. Shen
	2010
发表期刊	Journal of Materials Science-Materials in Medicine
ISSN	0957-4530
卷号	21 期号:7 页码:2151-2163
摘要	Biocorrosion properties and blood- and cell compatibility of pure iron were studied in comparison with 316L stainless steel and Mg-Mn-Zn magnesium alloy to reveal the possibility of pure iron as a biodegradable biomaterial. Both electrochemical and weight loss tests showed that pure iron showed a relatively high corrosion rate at the first several days and then decreased to a low level during the following immersion due to the formation of phosphates on the surface. However, the corrosion of pure iron did not cause significant increase in pH value to the solution. In comparison with 316L and Mg-Mn-Zn alloy, the pure iron exhibited biodegradable property in a moderate corrosion rate. Pure iron possessed similar dynamic blood clotting time, prothrombin time and plasma recalcification time to 316L and Mg-Mn-Zn alloy, but a lower hemolysis ratio and a significant lower number density of adhered platelets. MTT results revealed that the extract except the one with 25% 24 h extract actually displayed toxicity to cells and the toxicity increased with the increasing of the iron ion concentration and the incubation time. It was thought there should be an iron ion concentration threshold in the effect of iron ion on the cell toxicity.
部门归属	[zhang, erlin; chen, haiyan] chinese acad sci, inst met res, shenyang 110016, peoples r china. [chen, haiyan] chinese acad sci, grad univ, beijing 100049, peoples r china. [shen, feng] harbin inst technol, sch mat sci & engn, harbin 150001, peoples r china.;zhang, el (reprint author), chinese acad sci, inst met res, shenyang 110016, peoples r china;zhangerlin2009@163.com
关键词	316l Stainless-steel In-vitro Corrosion Biomedical Applications Mechanical-properties Surface Modification Magnesium Alloys Biocompatibility Toxicity Coagulation Overload
URL	查看原文
WOS记录号	WOS:000279592600017
引用统计	被引频次：120[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/31684
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	E. L. Zhang,H. Y. Chen,F. Shen. Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial[J]. Journal of Materials Science-Materials in Medicine,2010,21(7):2151-2163.
APA	E. L. Zhang,H. Y. Chen,&F. Shen.(2010).Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial.Journal of Materials Science-Materials in Medicine,21(7),2151-2163.
MLA	E. L. Zhang,et al."Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial".Journal of Materials Science-Materials in Medicine 21.7(2010):2151-2163.