Synthesis of PVP-coated ultra-small Fe(3)O(4) nanoparticles as a MRI contrast agent

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	Synthesis of PVP-coated ultra-small Fe(3)O(4) nanoparticles as a MRI contrast agent
	Y. Zhang; J. Y. Liu; S. Ma; Y. J. Zhang; X. Zhao; X. D. Zhang; Z. D. Zhang
	2010
发表期刊	Journal of Materials Science-Materials in Medicine
ISSN	0957-4530
卷号	21 期号:4 页码:1205-1210
摘要	Ultra-small Fe(3)O(4) nanoparticles were prepared by using the coprecipitation method, in which the polyvinylpyrrolidone (PVP) serves as a stabilizer. The nanoparticles were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), infra spectrum (IR), X-ray photoelectron spectroscopy (XPS) and in vivo magnetic resonance imaging (MRI) test. The results showed that the particles' size was determined by the dripping rate and that PVP molecules played the role of preventing the aggregation and restricting the size of Fe(3)O(4) nanoparticles. The Fe(3)O(4) nanoparticles with diameter from 6.5 to 1.9 nm obviously exhibited negative contrast enhancement and concentrated at the target area guided by a permanent magnet.
部门归属	[zhang, ying; ma, song; zhang, ya-jing; zhang, xiang-dong; zhang, zhi-dong] chinese acad sci, shenyang natl lab mat sci, inst met res, shenyang 110016, peoples r china. [zhang, ying; ma, song; zhang, ya-jing; zhang, xiang-dong; zhang, zhi-dong] chinese acad sci, int ctr mat phys, shenyang 110016, peoples r china. [zhang, ying; liu, jing-ying; zhao, xiang] shen yang pharmaceut univ, coll pharmaceut engn, shenyang 110016, peoples r china. [zhang, xiang-dong] liaoning univ, coll chem sci & engn, shenyang 110036, peoples r china.;zhang, y (reprint author), chinese acad sci, shenyang natl lab mat sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china;yzhang7704@imr.ac.cn
关键词	Iron-oxide Nanoparticles Size-controlled Synthesis Magnetite Nanoparticles W/o Microemulsion
URL	查看原文
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/31730
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	Y. Zhang,J. Y. Liu,S. Ma,et al. Synthesis of PVP-coated ultra-small Fe(3)O(4) nanoparticles as a MRI contrast agent[J]. Journal of Materials Science-Materials in Medicine,2010,21(4):1205-1210.
APA	Y. Zhang.,J. Y. Liu.,S. Ma.,Y. J. Zhang.,X. Zhao.,...&Z. D. Zhang.(2010).Synthesis of PVP-coated ultra-small Fe(3)O(4) nanoparticles as a MRI contrast agent.Journal of Materials Science-Materials in Medicine,21(4),1205-1210.
MLA	Y. Zhang,et al."Synthesis of PVP-coated ultra-small Fe(3)O(4) nanoparticles as a MRI contrast agent".Journal of Materials Science-Materials in Medicine 21.4(2010):1205-1210.