The preparation, cytocompatibility, and in vitro biodegradation study of pure beta-TCP on magnesium

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	The preparation, cytocompatibility, and in vitro biodegradation study of pure beta-TCP on magnesium
	F. Geng; L. L. Tan; X. X. Jin; J. Y. Yang; K. Yang
	2009
发表期刊	Journal of Materials Science-Materials in Medicine
ISSN	0957-4530
卷号	20 期号:5 页码:1149-1157
摘要	Biodegradable and bioactive beta-tricalcium phosphate (beta-TCP) coatings were prepared on magnesium (Mg) in order to improve its biocompatibility by a chemical method. The tensile bonding strength of beta-TCP coating and Mg substrate was measured by the standard adhesion test (ISO 13779-4). And the cytocompatibility of beta-TCP coated Mg was studied by using human osteoblast-like MG63 cells. It was found that the MG63 cells could grow well on the surface of beta-TCP coated Mg and the cell viability on beta-TCP coated Mg was above 80% during the cocultivation of MG63 cells and beta-TCP coated Mg for 10 days, indicating no cytotoxicity. It was concluded that the beta-TCP coated Mg had good cytocompatibility. The degradation of Mg substrate with beta-TCP coating in vitro was studied in detail by XRD, EDX, SEM, and ICP. The results showed that a bone-like apatite continually formed on the surface of the sample with the degradation of both Mg substrate and beta-TCP coating in Hank's solution (a simulated body fluid). The biodegradation mechanism was preliminarily analyzed in the paper.
部门归属	[geng, f.; tan, l. l.; yang, k.] chinese acad sci, inst met res, shenyang 110016, peoples r china. [geng, f.] chinese acad sci, grad sch, beijing 100049, peoples r china. [jin, x. x.; yang, j. y.] shenyang pharmaceut univ, dept pharmacol, shenyang 110016, peoples r china.;yang, k (reprint author), chinese acad sci, inst met res, shenyang 110016, peoples r china;kyang@imr.ac.cn
关键词	Simulated Body-fluid Corrosion Behavior Phosphate Ceramics Composite Coatings Microwave Irradiation Tricalcium Phosphate Bond Strength Hydroxyapatite Titanium Alloys
URL	查看原文
WOS记录号	WOS:000264837700015
引用统计	被引频次：87[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/31930
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	F. Geng,L. L. Tan,X. X. Jin,et al. The preparation, cytocompatibility, and in vitro biodegradation study of pure beta-TCP on magnesium[J]. Journal of Materials Science-Materials in Medicine,2009,20(5):1149-1157.
APA	F. Geng,L. L. Tan,X. X. Jin,J. Y. Yang,&K. Yang.(2009).The preparation, cytocompatibility, and in vitro biodegradation study of pure beta-TCP on magnesium.Journal of Materials Science-Materials in Medicine,20(5),1149-1157.
MLA	F. Geng,et al."The preparation, cytocompatibility, and in vitro biodegradation study of pure beta-TCP on magnesium".Journal of Materials Science-Materials in Medicine 20.5(2009):1149-1157.