Early effect of Ti-24Nb-4Zr-7.9Sn intramedullary nails on fractured bone

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	Early effect of Ti-24Nb-4Zr-7.9Sn intramedullary nails on fractured bone
	Z. Guo; J. Fu; Y. Q. Zhang; Y. Y. Hu; Z. G. Wu; L. Shi; M. Sha; S. J. Li; Y. L. Hao; R. Yang
	2009
发表期刊	Materials Science & Engineering C-Biomimetic and Supramolecular Systems
ISSN	0928-4931
卷号	29 期号:3 页码:963-968
摘要	A multifunctional titanium Ti-24Nb-4Zr-7.9Sn alloy (abbreviated as Ti2448) with ultra-low elastic modulus and high strength has been developed recently for potential biomedical applications. in this study, the bone healing and stability of implants in a rabbit tibial fracture model were investigated using intramedullary nails made of both the Ti2448 and Ti-6AI-4V ELI alloys. X-ray radiographic analysis showed that the volume fractions of new calluses formed around the fractured tibia increased with implantation times up to 4 weeks in both groups but no obvious difference was found between the alloys at the same time point. The micro-CT analysis revealed that, in the distal end of the tibia. there were many new calluses around nails made of the Ti2448 alloy that were confirmed by histological observations. The above analysis was consistent with tensile testing results performed 4 weeks after implantation. The mean maximum tensile force to failure of the newly formed Calluses was similar between both groups whereas the mean maximum pull-out forces of the implanted nails were larger in the group of the Ti2448 alloy. Four weeks after fixation, no obvious difference in the degree of fracture healing was found between both groups. These results suggested that, in the early stage of fixation, the nails with ultra-low elastic modulus improved the new bone formation in the marrow cavity. (C) 2008 Elsevier B.V. All rights reserved.
部门归属	[guo, z.; fu, j.; zhang, y. q.; hu, y. y.; wu, z. g.; shi, l.; sha, m.] fourth mil med univ, xijing hosp, inst orthopaed, xian 710032, peoples r china. [li, s. j.; hao, y. l.; yang, r.] chinese acad sci, shenyang natl lab mat sci, inst met res, shenyang 110016, peoples r china.;guo, z (reprint author), fourth mil med univ, xijing hosp, inst orthopaed, xian 710032, peoples r china;guozheng@fmmu.edu.cn ylhao@imr.ac.cn
关键词	Titanium Alloy Ultra-low Elastic Modulus Rabbits Stress Shielding Osseointegration Biomedical Applications Implants Stiffness Rabbits Alloys
URL	查看原文
WOS记录号	WOS:000266520400054
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/31942
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	Z. Guo,J. Fu,Y. Q. Zhang,et al. Early effect of Ti-24Nb-4Zr-7.9Sn intramedullary nails on fractured bone[J]. Materials Science & Engineering C-Biomimetic and Supramolecular Systems,2009,29(3):963-968.
APA	Z. Guo.,J. Fu.,Y. Q. Zhang.,Y. Y. Hu.,Z. G. Wu.,...&R. Yang.(2009).Early effect of Ti-24Nb-4Zr-7.9Sn intramedullary nails on fractured bone.Materials Science & Engineering C-Biomimetic and Supramolecular Systems,29(3),963-968.
MLA	Z. Guo,et al."Early effect of Ti-24Nb-4Zr-7.9Sn intramedullary nails on fractured bone".Materials Science & Engineering C-Biomimetic and Supramolecular Systems 29.3(2009):963-968.