In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy

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	In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy
	L. P. Xu; F. Pan; G. N. Yu; L. Yang; E. L. Zhang; K. Yang
	2009
发表期刊	Biomaterials
ISSN	0142-9612
卷号	30 期号:8 页码:1512-1523
摘要	Magnesium has shown potential application as a bio-absorbable biomaterial, Such as for bone screws and plates. In order to improve the Surface bioactivity. a calcium phosphate was coated oil a magnesium alloy by a phosphating process (Ca-P coating). The Surface characterization showed that a porous and netlike CaGPO(4)center dot 2H(2)O layer with small amounts of Mg(21) and Zn(21) was formed oil the surface of the Mg alloy. Cells L929 showed significantly good adherence and significantly high growth rate and proliferation characteristics oil the Ca-P coated magnesium alloy (p < 0.05) in in-vitro cell experiments, demonstrating that the Surface cytocompatibility of magnesium was significantly improved by the Ca-P coating. In vivo implantations of the Ca-P coated and the naked alloy rods were carried Out to investigate the bone response at the early stage. Both routine pathological examination and immunohistochemical analysis demonstrated that the Ca-P coating provided magnesium with a significantly good Surface bioactivity (p < 0.05) and promoted early bone growth at the implant/bone interface. It Was suggested that the Ca-P coating might be all effective method to improve the surface bioactivity of magnesium alloy. (C) 2008 Elsevier Ltd. All rights reserved.
部门归属	[xu, liping; yang, lei; zhang, erlin; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [xu, liping; yang, lei] chinese acad sci, grad univ, beijing 100049, peoples r china. [pan, feng] china med univ, shenyang 110001, peoples r china. [zhang, erlin] jiamusi univ, jiamusi 154007, peoples r china. [yu, guoning] peoples hosp liaoning prov, shenyang 110016, peoples r china.;zhang, el (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china;erlin.zhang@imr.ac.cn
关键词	Magnesium Calcium Phosphate Coating Bioactivity Biocompatility Bone In Vitro Rest Bone Implant Application Simulated Body-fluid Corrosion Properties Biomedical Applications Osteoblast Adhesion Mg Zinc Hydroxyapatite Titanium Ti
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WOS记录号	WOS:000263402500007
引用统计	被引频次：432[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/32459
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	L. P. Xu,F. Pan,G. N. Yu,et al. In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy[J]. Biomaterials,2009,30(8):1512-1523.
APA	L. P. Xu,F. Pan,G. N. Yu,L. Yang,E. L. Zhang,&K. Yang.(2009).In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy.Biomaterials,30(8),1512-1523.
MLA	L. P. Xu,et al."In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy".Biomaterials 30.8(2009):1512-1523.