Surface microstructure and cell biocompatibility of silicon-substituted hydroxyapatite coating on titanium substrate prepared by a biomimetic process

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	Surface microstructure and cell biocompatibility of silicon-substituted hydroxyapatite coating on titanium substrate prepared by a biomimetic process
	E. Zhang; C. M. Zou; G. N. Yu
	2009
发表期刊	Materials Science & Engineering C-Biomimetic and Supramolecular Systems
ISSN	0928-4931
卷号	29 期号:1 页码:298-305
摘要	Silicon-substituted hydroxyapatite (Si-HA) coatings with 0.14 to 1.14 at.% Si on pure titanium were prepared by a biomimetic process. The microstructure characterization and the cell compatibility of the Si-HA coatings were studied in comparison with that of hydroxyapatite (HA) coating prepared in the same way, The prepared Si-HA coatings and HA coating were only partially crystallized or in nano-scaled crystals. The introduction of Si element in HA significantly reduced P and Ca content, but densified the coating. The atom ratio of Ca to (P+Si) in the Si-HA coatings was in a range of 1.61-1.73, increasing slightly with an increase in the Si content. FTIR results displayed that Si entered HA in a form of SiO(4) unit by substituting for PO(4) unit. The cell attachment test showed that the HA and Si-HA coatings exhibited better cell response than the uncoated titanium, but no difference was observed in the cell response between the HA coating and the Si-HA coatings. Both the HA coating and the Si-HA coatings demonstrated a significantly higher cell growth rate than the uncoated pure titanium (p < 0.05) in all incubation periods while the Si-HA coating exhibited a significantly higher cell growth rate than the HA coating (p < 0.05). Si-HA with 0.42 at.% Si presented the best cell biocompatibility in all of the incubation periods. It was suggested that the synthesis mode of HA and Si-HA coatings in a simulated body environment in the biomimetic process contribute significantly to good cell biocompatibility. (c) 2008 Elsevier B.V. All rights reserved.
部门归属	[zhang, erlin] chinese acad sci, inst met res, shenyang 110016, peoples r china. [zou, chunming] harbin inst technol, sch mat sci & engn, harbin 150001, peoples r china. [yu, guoning] peoples hosp liaoning prov, shenyang 110000, peoples r china.;zhang, e (reprint author), chinese acad sci, inst met res, shenyang 110016, peoples r china;erln.zhang@imr.ac.cn
关键词	Biomimetic Coating Silicon-substituted Hydroxyapatite Titanium Biocompatibility Calcium-phosphate Coatings Thin-films Si-ha Deposition Bone Dissolution Apatite Spectroscopy Bioceramics Attachment
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WOS记录号	WOS:000262136700049
引用统计	被引频次：46[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/32526
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	E. Zhang,C. M. Zou,G. N. Yu. Surface microstructure and cell biocompatibility of silicon-substituted hydroxyapatite coating on titanium substrate prepared by a biomimetic process[J]. Materials Science & Engineering C-Biomimetic and Supramolecular Systems,2009,29(1):298-305.
APA	E. Zhang,C. M. Zou,&G. N. Yu.(2009).Surface microstructure and cell biocompatibility of silicon-substituted hydroxyapatite coating on titanium substrate prepared by a biomimetic process.Materials Science & Engineering C-Biomimetic and Supramolecular Systems,29(1),298-305.
MLA	E. Zhang,et al."Surface microstructure and cell biocompatibility of silicon-substituted hydroxyapatite coating on titanium substrate prepared by a biomimetic process".Materials Science & Engineering C-Biomimetic and Supramolecular Systems 29.1(2009):298-305.