In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation

IMR OpenIR

	In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation
	E. L. Zhang; L. P. Xu; G. N. Yu; F. Pan; K. Yang
	2009
发表期刊	Journal of Biomedical Materials Research Part A
ISSN	1549-3296
卷号	90A 期号:3 页码:882-893
摘要	In vivo degradation of magnesium alloy implant, the bone response to the magnesium, and the effect of the degradation of magnesium on the blood composition and organs were investigated by using light microscopy and scanning electronic microscopy with energy dispersive spectrum. Magnesium alloy showed different degradation rates in the marrow channel and the cortical bone. More degradation of magnesium implant was observed in the marrow channel than in the cortical bone. New bone tissue formed around the magnesium implants after 6 weeks implantation but no fibrous capsule was found. There existed two distinct layers separating the new bone tissue from the magnesium implant. On the magnesium implant side, crystalline magnesium calcium phosphate formed oil the surface of the implant due to the reaction between the implant and blood or body fluid. On the new bone tissue side was a 10-30-mu m membrane comprising two distinct layers with many fibroblasts in the layer close to the new bone tissue. The new bone was in tight contact with the implant through the membrane and phosphate layer due to the good osteoconductivity of the phosphate layer. After 10 and 26 weeks postimplantation, more new bone tissues as well as the membrane were found around the implant. However, no apparent increase in the thickness of the membrane was observed with the increasing of the implantation duration. Blood examination has shown that the degradation of the magnesium implant caused little change to blood composition but no disorder to liver or kidneys. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 882-893, 2009
部门归属	[zhang, erlin] jiamusi univ, sch mat sci & engn, jiamusi 154007, peoples r china. [zhang, erlin; xu, liping; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [yu, guoning; pan, feng] china med univ, shenyang 110001, peoples r china.;zhang, el (reprint author), jiamusi univ, sch mat sci & engn, jiamusi 154007, peoples r china;erlin.zhang@imr.ac.cn
关键词	Magnesium Alloy Bone Healing In Vivo Test Degradation Osteoconduction Commercially Pure Titanium Corrosion Behavior Stainless-steel Hanks Solution Mg Interface Surface Vitro Goat
URL	查看原文
WOS记录号	WOS:000268860100028
引用统计	被引频次：216[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/32528
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	E. L. Zhang,L. P. Xu,G. N. Yu,et al. In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation[J]. Journal of Biomedical Materials Research Part A,2009,90A(3):882-893.
APA	E. L. Zhang,L. P. Xu,G. N. Yu,F. Pan,&K. Yang.(2009).In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation.Journal of Biomedical Materials Research Part A,90A(3),882-893.
MLA	E. L. Zhang,et al."In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation".Journal of Biomedical Materials Research Part A 90A.3(2009):882-893.