Effect of surface micro-topography of titanium material on the behaviors of rabbit osteoblast in vitro

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	Effect of surface micro-topography of titanium material on the behaviors of rabbit osteoblast in vitro
	J. Fu; Y. Y. Hu; Z. Guo; Y. Q. Zhang; Y. L. Hao; S. J. Li
	2008
发表期刊	Applied Surface Science
ISSN	0169-4332
卷号	255 期号:2 页码:286-289
摘要	To study interactions of osteoblast on different topography surfaces of titanium material through in vitro systems, four kinds of micro-topography surfaces on novel titanium material were investigated. They were laser-scanned surface (LS), sandblasted surface (SS), machine-tooled surface (MS) and polished surface (PS). The titanium samples were seeded with osteoblast and maintained for a period of 1-12 days. Adhesion in 24 h, proliferation in 12 days and ALP activity in 11 days were assessed. The cell morphologies were observed by scanning electron microscopy and fluorescence microscopy. The investigation showed better cell proliferation and best cell osteogenic differentiation on the micro-grooved surface (LS) at the cell scale (50 mm). Furthermore, osteoblast on the micro-grooved surfaces also displayed a more similar morphology to osteoblast in vivo. It was shown that surface micro-texture at the cell scale have a better effect on cell responses than rough surface and surface texture above the cell scale (> 100 mu m). The regular micro-grooved titanium surface at the cell scale can offer a better cell growth environment compared with the other titanium surfaces. (C) 2008 Elsevier B. V. All rights reserved.
部门归属	[fu, jun; hu, yunyu; guo, zheng; zhang, yongquan] fourth mil med univ, xijing hosp, inst orthopaed, xian 710032, peoples r china. [hao, yulin; li, shujun] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, peoples r china.;guo, z (reprint author), fourth mil med univ, xijing hosp, inst orthopaed, xian 710032, peoples r china;guozheng@fmmu.edu.cn
关键词	Titanium Surface Micro-topography Roughness Osteoblast Biomedical Applications Growth Cells Substratum Morphology Bone
URL	查看原文
WOS记录号	WOS:000260510600011
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/32762
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	J. Fu,Y. Y. Hu,Z. Guo,et al. Effect of surface micro-topography of titanium material on the behaviors of rabbit osteoblast in vitro[J]. Applied Surface Science,2008,255(2):286-289.
APA	J. Fu,Y. Y. Hu,Z. Guo,Y. Q. Zhang,Y. L. Hao,&S. J. Li.(2008).Effect of surface micro-topography of titanium material on the behaviors of rabbit osteoblast in vitro.Applied Surface Science,255(2),286-289.
MLA	J. Fu,et al."Effect of surface micro-topography of titanium material on the behaviors of rabbit osteoblast in vitro".Applied Surface Science 255.2(2008):286-289.