In vivo corrosion behavior of Mg-Mn-Zn alloy for bone implant application

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	In vivo corrosion behavior of Mg-Mn-Zn alloy for bone implant application
	L. P. Xu; G. N. Yu; E. Zhang; F. Pan; K. Yang
	2007
发表期刊	Journal of Biomedical Materials Research Part A
ISSN	1549-3296
卷号	83A 期号:3 页码:703-711
摘要	Magnesium alloy has been implanted in rats to investigate the in vivo degradation behavior of magnesium for bone implant application. After 9 weeks postoperation, 100% implants were fixed and no inflammation was observed. Histological analysis showed new bone was formed around magnesium implant and no difference was found in the histological microstructure of the new bone and the cortical bone. A degradation or reaction layer, which was mainly composed of Ca, P, O, and Mg, was formed on the surface of magnesium alloy implants. High Ca content in the degradation layer displayed that magnesium could promote the deposition of Ca. Residual area calculation has showed that 10-17% magnesium alloy implant has been degraded in vivo. Compared with that of the controlled rats, no increase in serum magnesium and no disorder of kidney were observed after 15 weeks postoperation. After 18 weeks postoperation, 100% magnesium implants were fixed and no inflammation was observed. About 54% magnesium implant has degraded in vivo. Element analysis showed that Zn and Mn in Mg-Mn-Zn alloy distributed homogeneously in the residual magnesium implant, the degradation layer, and the surrounding bone tissue after 18 weeks implantation, indicating that Zn and Mn elements were easily absorbed by bioenvironment. (C) 2007 Wiley Periodicals, Inc.
部门归属	chinese acad sci, inst met res, shenyang 110016, peoples r china. china med univ, dept orthoped surg, shenyang 110001, peoples r china.;zhang, e (reprint author), chinese acad sci, inst met res, shenyang 110016, peoples r china;erlin.zhang@imr.ac.cn
关键词	Biomaterials Magnesium Alloy Biocorrosion Bone Implant Calcium-phosphate Magnesium Alloys Biometallic Materials Tissue-response Hanks Solution Titanium Surface Deposition Apatite
URL	查看原文
WOS记录号	WOS:000250742700015
引用统计	被引频次：470[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/33952
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	L. P. Xu,G. N. Yu,E. Zhang,et al. In vivo corrosion behavior of Mg-Mn-Zn alloy for bone implant application[J]. Journal of Biomedical Materials Research Part A,2007,83A(3):703-711.
APA	L. P. Xu,G. N. Yu,E. Zhang,F. Pan,&K. Yang.(2007).In vivo corrosion behavior of Mg-Mn-Zn alloy for bone implant application.Journal of Biomedical Materials Research Part A,83A(3),703-711.
MLA	L. P. Xu,et al."In vivo corrosion behavior of Mg-Mn-Zn alloy for bone implant application".Journal of Biomedical Materials Research Part A 83A.3(2007):703-711.