Fibroblast adhesion and proliferation on a new beta type Ti-39Nb-13Ta-4.6Zr alloy for biomedical application

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	Fibroblast adhesion and proliferation on a new beta type Ti-39Nb-13Ta-4.6Zr alloy for biomedical application; Fibroblast adhesion and proliferation on a new beta type Ti-39Nb-13Ta-4.6Zr alloy for biomedical application
	Y. K. Zhao; Y. Yao; W. X. Liu; C. Y. Zheng; S. J. Li
	2006 ; 2006
发表期刊	Journal of Materials Science & Technology ; Journal of Materials Science & Technology
ISSN	1005-0302 ; 1005-0302
卷号	22 期号:2 页码:205-210
摘要	Cell attachment and spreading on Ti-based alloy surfaces is a major parameter in implant technology. Ti39Nb-13Ta-4.6Zr alloy is a new beta type Ti alloy developed for biomedical application. This alloy has low modulus and high strength, which indicates that it can be used for medical purposes such as surgical implants. To evaluate the biocompatibility and effects of the surface morphology of Ti-39Nb-13Ta-4.6Zr on the cellular behaviour, the adhesion and proliferation of rat gingival fibroblasts were studied with substrates having different surface roughness and the results were also compared with commercial pure titanium and Ti-6Al-4V. The results indicate that fibroblast shows similar adhesion and proliferation on the smooth surfaces of commercial pure titanium (Cp Ti), Ti-39Nb-13Ta-4.6Zr, and Ti-6Al-4V, suggesting that Ti-39Nb-13Ta-4.6Zr has similar biocompatibility to Cp Ti and Ti-6Al-4V. The fibroblast adhesion and spreading was lower on rough surfaces of Cp Ti, Ti-39Nb-13Ta-4.6Zr and Ti-6Al-4V than on smooth ones. Surface roughness appeared to be a dominant factor that determines the fibroblast adhesion and proliferation.; Cell attachment and spreading on Ti-based alloy surfaces is a major parameter in implant technology. Ti39Nb-13Ta-4.6Zr alloy is a new beta type Ti alloy developed for biomedical application. This alloy has low modulus and high strength, which indicates that it can be used for medical purposes such as surgical implants. To evaluate the biocompatibility and effects of the surface morphology of Ti-39Nb-13Ta-4.6Zr on the cellular behaviour, the adhesion and proliferation of rat gingival fibroblasts were studied with substrates having different surface roughness and the results were also compared with commercial pure titanium and Ti-6Al-4V. The results indicate that fibroblast shows similar adhesion and proliferation on the smooth surfaces of commercial pure titanium (Cp Ti), Ti-39Nb-13Ta-4.6Zr, and Ti-6Al-4V, suggesting that Ti-39Nb-13Ta-4.6Zr has similar biocompatibility to Cp Ti and Ti-6Al-4V. The fibroblast adhesion and spreading was lower on rough surfaces of Cp Ti, Ti-39Nb-13Ta-4.6Zr and Ti-6Al-4V than on smooth ones. Surface roughness appeared to be a dominant factor that determines the fibroblast adhesion and proliferation.
部门归属	china med univ, affiliated hosp 2, shenyang 110004, peoples r china. chinese acad sci, inst met res, shenyang 110016, peoples r china.;zhao, yk (reprint author), china med univ, affiliated hosp 2, shenyang 110004, peoples r china;yyzhyk@163.com ; china med univ, affiliated hosp 2, shenyang 110004, peoples r china. chinese acad sci, inst met res, shenyang 110016, peoples r china.;zhao, yk (reprint author), china med univ, affiliated hosp 2, shenyang 110004, peoples r china;yyzhyk@163.com
关键词	Biomaterials Biomaterials Titanium Alloys Titanium Alloys Fibroblast Fibroblast Adhesion Adhesion Proliferation Proliferation Surface Roughness Surface Roughness Nb-ta-zr Nb-ta-zr Osteoblast-like Cells Osteoblast-like Cells Surface-roughness Surface-roughness Titanium Surfaces Titanium Surfaces Epithelial-cells Epithelial-cells Ti-6al-4v Ti-6al-4v
URL	查看原文 ; 查看原文
WOS记录号	WOS:000236590000013 ; WOS:000236590000013
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/34747
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	Y. K. Zhao,Y. Yao,W. X. Liu,et al. Fibroblast adhesion and proliferation on a new beta type Ti-39Nb-13Ta-4.6Zr alloy for biomedical application, Fibroblast adhesion and proliferation on a new beta type Ti-39Nb-13Ta-4.6Zr alloy for biomedical application[J]. Journal of Materials Science & Technology, Journal of Materials Science & Technology,2006, 2006,22, 22(2):205-210, 205-210.
APA	Y. K. Zhao,Y. Yao,W. X. Liu,C. Y. Zheng,&S. J. Li.(2006).Fibroblast adhesion and proliferation on a new beta type Ti-39Nb-13Ta-4.6Zr alloy for biomedical application.Journal of Materials Science & Technology,22(2),205-210.
MLA	Y. K. Zhao,et al."Fibroblast adhesion and proliferation on a new beta type Ti-39Nb-13Ta-4.6Zr alloy for biomedical application".Journal of Materials Science & Technology 22.2(2006):205-210.