Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants

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	Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants
	T. C. Ma; P. Wan; Y. Y. Cui; G. R. Zhang; J. Q. Li; J. H. Liu; Y. B. Ren; K. Yang; L. Lu
	2012
发表期刊	Journal of Materials Science & Technology
ISSN	1005-0302
卷号	28 期号:7 页码:647-653
摘要	Cytocompatibility of high nitrogen nickel-free stainless steel (HNS) with different nitrogen content was evaluated and compared with a conventional austenitic stainless steel 317L. The MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was performed on MG63 osteoblasts to assess the cytotoxicity. The expression of selected marker typical of differentiated osteoblasts, such as alkaline phosphatase activity (AKP), was also monitored in MG63 cells cultured on the tested materials. As a result, HNS had higher cell growth than 317L; meanwhile the cytocompatibility was increased with increasing nitrogen content. Furthermore, HNS enhanced osteoblasts differentiation, as confirmed by AKP activity. Overall these facts indicated that HNS had higher cytocompatibility than 317L and the nitrogen content contributed to the higher cytocompatibility of HNS. The influence of nitrogen on surface energy further explained the cytocompatibility of HNS.
部门归属	[ma, tianchi; lu, li] china med univ, sch stomatol, shenyang 110002, peoples r china. [wan, peng; ren, yibin; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [cui, yuyan] shenyang fourth hosp people, shenyang 110032, peoples r china. [ma, tianchi; zhang, guirong; li, jiqiang; liu, jihui] shenyang stomatoi hosp, shenyang 110002, peoples r china.;lu, l (reprint author), china med univ, sch stomatol, shenyang 110002, peoples r china.;lilucmu@gmail.com
关键词	High Nitrogen Stainless Steel Cytoxicity Evaluation Osteoblasts Bone Surface Energy Partially-stabilized Zirconia In-vitro Surface-roughness Adhesion Wettability Adsorption Corrosion Bone
URL	查看原文
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/60155
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	T. C. Ma,P. Wan,Y. Y. Cui,et al. Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants[J]. Journal of Materials Science & Technology,2012,28(7):647-653.
APA	T. C. Ma.,P. Wan.,Y. Y. Cui.,G. R. Zhang.,J. Q. Li.,...&L. Lu.(2012).Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants.Journal of Materials Science & Technology,28(7),647-653.
MLA	T. C. Ma,et al."Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants".Journal of Materials Science & Technology 28.7(2012):647-653.