Investigation of Biological Property of Nanohydroxyapatite Materials

IMR OpenIR

	Investigation of Biological Property of Nanohydroxyapatite Materials
	X. F. Pang; H. W. Zhou; J. L. Liu
	2012
发表期刊	Journal of Nanoscience and Nanotechnology
ISSN	1533-4880
卷号	12 期号:2 页码:894-901
摘要	The biological effects of nanohydroxyapatites and its cell toxicity have been studied using the MU and ALP method, infrared spectrum of absorption and electrophoresis method, respectively. The nanohydroxyapatites are prepared and made by using sol-gel method, in which the parameters of process and reaction are controlled as: pH > 9, Ca/P = 1.67, sintering temperature of 1100 degrees C and sintering time 2 hours. Studied results show that nanohydroxyapatites can interact with human serum albumin and change its second structure and weight of molecules. We find that the nanohydroxyapatites and complex of nanoHAP + nanoCrO(2) can all restrain the proliferation of MG63 cells, but their toxicities are first degree or minor, the toxicity of the complex is smaller than that of pure nanohydroxyapatites.
部门归属	[pang, xiao-feng; zhou, hong-wei; liu, jia-lie] univ elect sci & technol china, inst life sci & technol, chengdu 610054, peoples r china. [pang, xiao-feng] chinese acad sci, int ctr mat phys, shenyang 110015, peoples r china.;pang, xf (reprint author), univ elect sci & technol china, inst life sci & technol, chengdu 610054, peoples r china.
关键词	Nanohydroxyapatite Cell Proliferation Biological Function Toxicity Infrared Spectrum Electrophoresis Human Serum Albumin Molecular Structure Nano-hydroxyapatite In-vitro Nanoparticles Proteins Nanostructures Cytotoxicity Ir
URL	查看原文
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/60187
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	X. F. Pang,H. W. Zhou,J. L. Liu. Investigation of Biological Property of Nanohydroxyapatite Materials[J]. Journal of Nanoscience and Nanotechnology,2012,12(2):894-901.
APA	X. F. Pang,H. W. Zhou,&J. L. Liu.(2012).Investigation of Biological Property of Nanohydroxyapatite Materials.Journal of Nanoscience and Nanotechnology,12(2),894-901.
MLA	X. F. Pang,et al."Investigation of Biological Property of Nanohydroxyapatite Materials".Journal of Nanoscience and Nanotechnology 12.2(2012):894-901.