In vitro study of role of trace amount of Cu release from Cu-bearing stainless steel targeting for reduction of in-stent restenosis

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	In vitro study of role of trace amount of Cu release from Cu-bearing stainless steel targeting for reduction of in-stent restenosis
	L. Ren; L. Xu; J. W. Feng; Y. Zhang; K. Yang
	2012
发表期刊	Journal of Materials Science-Materials in Medicine
ISSN	0957-4530
卷号	23 期号:5 页码:1235-1245
摘要	A novel 316L type Cu-bearing stainless steel was developed in present work, aiming at reducing the occurrence of the in-stent restenosis after implantations of coronary stents, through trace amount of Cu release from surface of the steel in body fluid. It was found that there was a trace amount of Cu released from the Cu-bearing steel in a simulated body fluid, with no cytotoxicity. All the in vitro experimental results proved that this Cu-bearing steel could not only inhibit the proliferation of vascular smooth muscle cells, reducing the formation of thrombosis, which are the main reasons for happening of the in-stent restenosis, but also promote the proliferation of vascular endothelial cells needed for the revascularization, showing that this novel steel is prospective to be a new material for manufacturing coronary stents with function of reducing the in-stent restenosis.
部门归属	[ren, ling; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [ren, ling] chinese acad sci, grad sch, beijing 100049, peoples r china. [xu, lu; feng, jingwen; zhang, yang] china med univ, shenyang 110001, peoples r china.;yang, k (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china.;lren@imr.ac.cn; yyxulu@163.com; jingwen8719@126.com; zhangyangcmu@yahoo.com.cn; kyang@imr.ac.cn
关键词	Copper Deficiency Mechanisms Thrombosis Platelets Rats Mice Era
URL	查看原文
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/60200
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	L. Ren,L. Xu,J. W. Feng,et al. In vitro study of role of trace amount of Cu release from Cu-bearing stainless steel targeting for reduction of in-stent restenosis[J]. Journal of Materials Science-Materials in Medicine,2012,23(5):1235-1245.
APA	L. Ren,L. Xu,J. W. Feng,Y. Zhang,&K. Yang.(2012).In vitro study of role of trace amount of Cu release from Cu-bearing stainless steel targeting for reduction of in-stent restenosis.Journal of Materials Science-Materials in Medicine,23(5),1235-1245.
MLA	L. Ren,et al."In vitro study of role of trace amount of Cu release from Cu-bearing stainless steel targeting for reduction of in-stent restenosis".Journal of Materials Science-Materials in Medicine 23.5(2012):1235-1245.