| Preliminary study of anti-infective function of a copper-bearing stainless steel |
| L. Ren; K. Yang; L. Guo; H. W. Chai
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| 2012
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| 发表期刊 | Materials Science & Engineering C-Materials for Biological Applications
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| ISSN | 0928-4931
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| 卷号 | 32期号:5页码:1204-1209 |
| 摘要 | In this study the copper (Cu)-bearing stainless steel was developed to reduce the incidence of implant-associated infections in clinical areas. A 317L austenitic stainless steel containing 4.5% Cu (317L-Cu SS) was designed and fabricated, and its anti-infective function was preliminarily studied both in vitro and in vivo by means of antibacterial test, confocal laser scanning microscope (CLSM) and scanning electron microscopy (SEM) observations, and animal implantation. The results indicated that the 317L-Cu SS possessed strong antibacterial rates against both Escherichia coil and Staphylococcus aureus, and showed anti-infective ability by inhibiting the formation of bacterial bio-film on surface of the steel due to the release of Cu ions from the steel surface. The microbiological and histological evaluations from animal implantation further proved that the 317L-Cu SS could obviously reduce the happening of bacterial infection, and is potential to be used as a new class of surgical implant material with anti-infective function. (C) 2012 Elsevier B.V. All rights reserved. |
| 部门归属 | [ren, ling; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [ren, ling] chinese acad sci, grad sch, beijing 100049, peoples r china. [guo, lei; chai, hong-wei] china med univ, hosp 1, shenyang 110001, peoples r china.;yang, k (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china.;lren@imr.ac.cn; kyang@imr.ac.cn; g527@sina.com; hongwei0310@126.com
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| 关键词 | Bacterial Infection
Cu-bearing
Antibacterial Stainless Steel
Anti-infection
Antibacterial Properties
Staphylococcus-aureus
Corrosion-resistance
Infections
Biofilms
Osteomyelitis
Bacteria
Metals
Model
Ions
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| URL | 查看原文
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.imr.ac.cn/handle/321006/60201
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| 专题 | 中国科学院金属研究所
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推荐引用方式
GB/T 7714 |
L. Ren,K. Yang,L. Guo,et al. Preliminary study of anti-infective function of a copper-bearing stainless steel[J]. Materials Science & Engineering C-Materials for Biological Applications,2012,32(5):1204-1209.
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| APA |
L. Ren,K. Yang,L. Guo,&H. W. Chai.(2012).Preliminary study of anti-infective function of a copper-bearing stainless steel.Materials Science & Engineering C-Materials for Biological Applications,32(5),1204-1209.
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| MLA |
L. Ren,et al."Preliminary study of anti-infective function of a copper-bearing stainless steel".Materials Science & Engineering C-Materials for Biological Applications 32.5(2012):1204-1209.
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