| Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells |
| Y. Zhang; L. Ren; M. Li; X. Lin; H. F. Zhao; K. Yang
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| 2012
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| 发表期刊 | Journal of Materials Science & Technology
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| ISSN | 1005-0302
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| 卷号 | 28期号:9页码:769-772 |
| 摘要 | Biodegradation of magnesium (Mg) based metals in body fluid can lead to a strong alkalinity as well as an increase of Mg2+ concentration in its surrounding environment. In vitro cytotoxic effects of the extracts of pure Mg with and without micro arc oxidation (MAO) coating on osteosarcoma U2-OS cells, a kind of bone cancer cells, were preliminarily studied, independently considering the increase of either alkalinity or Mg2+ concentration. The results indicated that the high alkalinity, i.e., a great increase of pH value, caused by the degradations of Mg with and without MAO coating in the culture medium all showed strong cytotoxic effects on U2-OS cells. However, the increase of Mg2+ concentration had no such cytotoxic effect. This finding may provide an alternative way to cure bone cancers through creating a high alkalinity surrounding the cancer cells. |
| 部门归属 | [ren, ling; lin, xiao; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [zhang, yu; li, mei; zhao, huafu] guangzhou mil command, guangzhou gen hosp, dept orthoped surg, guangzhou 510010, guangdong, peoples r china.;yang, k (reprint author), chinese acad sci, inst met res, shenyang 110016, peoples r china.;kyang@imr.ac.cn
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| 关键词 | Magnesium
Biodegradation
Alkalinity
Cancer Cell
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| URL | 查看原文
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.imr.ac.cn/handle/321006/60463
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| 专题 | 中国科学院金属研究所
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推荐引用方式
GB/T 7714 |
Y. Zhang,L. Ren,M. Li,et al. Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells[J]. Journal of Materials Science & Technology,2012,28(9):769-772.
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| APA |
Y. Zhang,L. Ren,M. Li,X. Lin,H. F. Zhao,&K. Yang.(2012).Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells.Journal of Materials Science & Technology,28(9),769-772.
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| MLA |
Y. Zhang,et al."Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells".Journal of Materials Science & Technology 28.9(2012):769-772.
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