TiC/Ti复合泡沫材料的制备及生物学性能研究

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	TiC/Ti复合泡沫材料的制备及生物学性能研究
	高勇
学位类型	博士
导师	张劲松
	2012
学位授予单位	中国科学院金属研究所
学位授予地点	北京
学位专业	材料加工工程
关键词	Tic/ti复合泡沫材料高频感应加热力学性能表面改性生物材料 Tic/ti Composite Foam Materials High Frequency Induction Heating Mechanical Properties Surface Modification Biomaterials
其他摘要	" 生物材料（Biomaterials）是以独立体形式或作为复杂系统的一部分，通过与生命系统组成部分的相互作用，用于引导人体或动物体医学中任何治疗或诊断过程的一种物质，是研究人工器官和医疗器械的基础。随着社会老龄化趋势的加剧、交通意外事故发生率的上升，以及战争损伤的持续存在，临床上对大范围骨缺损的修复材料的需求快速增加。因此，作为至今仍是临床难题的大段骨缺损修复，其所需生物材料的研究和应用依然需要更多的学术关注与研发投入。本论文在Schwartzwalder法基础上，采用高频感应加热为材料制备的主要手段，通过建立数值模拟计算模型，对制备工艺参数进行模拟优化。制得含有TiC、Ti的具有三维连通网络结构的新型泡沫材料——TiC/Ti复合泡沫材料。研究了制备工艺-材料组织结构-材料性能之间的相互关系。随着Ti含量的增加，泡沫骨架筋内孔隙逐步被填充，组织致密化，泡沫骨架筋在断裂时体现的脆性断裂行为的比重呈降低趋势。当钛含量为80at%时，平均孔径1mm，孔隙率80%的TiC/Ti复合泡沫材料抗表观压缩应力-表观压缩应变曲线体现出部分塑性。采用水热合成法对TiC/Ti复合泡沫材料骨架筋表面分别修饰纳米TiO2涂层和ZSM-5涂层。纳米TiO2涂层由大量TiO2线状纳米结构相互缠绕构成，其间分布大量纳米级孔隙。ZSM-5涂层由大量分子筛晶体堆积构成，其内孔隙主要由晶间孔隙构成。两种涂层的均方根粗糙度分别为233.6nm和146.8nm。以同样具有三维连通网络结构的SiC泡沫材料为对照组，对原始TiC/Ti复合泡沫材料、表面修饰纳米TiO2的TiC/Ti复合泡沫材料、表面修饰ZSM-5分子筛的TiC/Ti复合泡沫材料进行体内、体外生物相容性测试。结果显示，三种实验组材料的生物相容性和骨整合性能由高到低依次为：原始TiC/Ti复合泡沫材料、表面修饰纳米TiO2的TiC/Ti复合泡沫材料、SiC泡沫材料、表面修饰ZSM-5分子筛的TiC/Ti复合泡沫材料。 " ; " Biomaterials is a kind of substances that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure, in human or veterinary medicine. It is the basis for developing artificial organ and medical devices. As the increased tendency of aging society, traffic accidents, and war injuries, the clinic need for bone repair biomaterials in large-scale bone defects rises rapidly. Therefore, much more acdemic attention and capital investment should be placed on the R&D of such kind of biomaterials. Based on the Schwartzwalder method and numerical simulation of process parameters of high frequency inductive heating, a novel kind of foam materials with 3-D interconnected open-cell, TiC/Ti composite foam materials, is prepared in the present work. The interrelationship among process parameters, microstructure and properties of the fabricated materials is studied. With the increase of Ti at%, the foam struts are densified; while the brittleness of the foam materials decreased. The apparent compressive stress-strain curve of the TiC/Ti composite foam materials shows kind of plasticity, with a titanium content of 80 at %, average pore size of 1mm, and porosity of 80%. By hydrothermal synthesis method, the surface of the TiC/Ti foam was modified with nano TiO2 and ZSM-5. The nanowire TiO2 coating is composed of a large amount of interwined TiO2 nanowire and nanosize pores. The ZSM-5 coating is constructed with numerous ZSM-5 crystals of several micron and pores. The roughness (Rq) of the ZSM-5 coating is 233.6nm, which is a little larger than that of the nano-TiO2 coating of 146.8nm. Using the bioinert SiC foam materials with the same 3-D interconnected open-cell structure as control group, in vitro and in vivo biocompatibility assessments are performed on the TiC/Ti composite foam materials, nano-TiO2 modified TiC/Ti composite foam materials and ZSM-5 modified TiC/Ti composite foam materials. The results show that the sequence of the biocompatibility and bone integration of the foam materials is as follows: TiC/Ti composite foam materials, nano TiO2 modified TiC/Ti composite foam materials, SiC foam materials, and ZSM-5 modified TiC/Ti composite foam materials "
文献类型	学位论文
条目标识符	http://ir.imr.ac.cn/handle/321006/64418
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	高勇. TiC/Ti复合泡沫材料的制备及生物学性能研究[D]. 北京. 中国科学院金属研究所,2012.