IMR OpenIR
Study of drug-eluting coating on metal coronary stent
S. S. Chen; L. L. Tan; Y. X. Teng; B. C. Zhang; K. Yang
2013
Source PublicationMaterials Science & Engineering C-Materials for Biological Applications
ISSN0928-4931
Volume33Issue:3Pages:1476-1480
AbstractDrug-eluting stent has been proved to decrease the restenosis caused by the stent implantation, owing to the existence of a drug-eluting coating on the stent. For ensuring the effectivity and security of the drug-eluting stent during the service period, the uniform surface, good deformation and stabilized drug release behavior of the stents should be satisfied. In this study, the performances mentioned were studied on stainless steel stents. The results showed that the surface morphology of the coating was affected by the sorts of solvent, the parameters of the spraying process and the addition of the plasticizer. The drug-eluting profile of the coating was influenced by the plasticizer content and PLGA/drug ratio of the coating. Meanwhile, the plasticizer as an additional agent obviously increased the deformation performance of the coating. Optimized parameters for preparation of the drug-eluting coating were investigated to obtain a drug-eluting coating with good integrated performances. (C) 2012 Elsevier B.V. All rights reserved.
description.department[chen shanshan ; tan lili ; teng yingxue ; zhang bingchun ; yang ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. ; tan, ll (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china. ; lltan@imr.ac.cn
KeywordDrug-eluting Stent Coating Surface Morphology Deformation Drug Releasing Behavior Balloon Angioplasty Coated Stents Implantation Release Artery Anticoagulation Restenosis Sirolimus Curcumin
URL查看原文
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/71164
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
S. S. Chen,L. L. Tan,Y. X. Teng,et al. Study of drug-eluting coating on metal coronary stent[J]. Materials Science & Engineering C-Materials for Biological Applications,2013,33(3):1476-1480.
APA S. S. Chen,L. L. Tan,Y. X. Teng,B. C. Zhang,&K. Yang.(2013).Study of drug-eluting coating on metal coronary stent.Materials Science & Engineering C-Materials for Biological Applications,33(3),1476-1480.
MLA S. S. Chen,et al."Study of drug-eluting coating on metal coronary stent".Materials Science & Engineering C-Materials for Biological Applications 33.3(2013):1476-1480.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[S. S. Chen]'s Articles
[L. L. Tan]'s Articles
[Y. X. Teng]'s Articles
Baidu academic
Similar articles in Baidu academic
[S. S. Chen]'s Articles
[L. L. Tan]'s Articles
[Y. X. Teng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[S. S. Chen]'s Articles
[L. L. Tan]'s Articles
[Y. X. Teng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.