Study of drug-eluting coating on metal coronary stent

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	Study of drug-eluting coating on metal coronary stent
	S. S. Chen; L. L. Tan; Y. X. Teng; B. C. Zhang; K. Yang
	2013
发表期刊	Materials Science & Engineering C-Materials for Biological Applications
ISSN	0928-4931
卷号	33 期号:3 页码:1476-1480
摘要	Drug-eluting stent has been proved to decrease the restenosis caused by the stent implantation, owing to the existence of a drug-eluting coating on the stent. For ensuring the effectivity and security of the drug-eluting stent during the service period, the uniform surface, good deformation and stabilized drug release behavior of the stents should be satisfied. In this study, the performances mentioned were studied on stainless steel stents. The results showed that the surface morphology of the coating was affected by the sorts of solvent, the parameters of the spraying process and the addition of the plasticizer. The drug-eluting profile of the coating was influenced by the plasticizer content and PLGA/drug ratio of the coating. Meanwhile, the plasticizer as an additional agent obviously increased the deformation performance of the coating. Optimized parameters for preparation of the drug-eluting coating were investigated to obtain a drug-eluting coating with good integrated performances. (C) 2012 Elsevier B.V. All rights reserved.
部门归属	[chen shanshan ; tan lili ; teng yingxue ; zhang bingchun ; yang ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. ; tan, ll (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china. ; lltan@imr.ac.cn
关键词	Drug-eluting Stent Coating Surface Morphology Deformation Drug Releasing Behavior Balloon Angioplasty Coated Stents Implantation Release Artery Anticoagulation Restenosis Sirolimus Curcumin
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/71164
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	S. S. Chen,L. L. Tan,Y. X. Teng,et al. Study of drug-eluting coating on metal coronary stent[J]. Materials Science & Engineering C-Materials for Biological Applications,2013,33(3):1476-1480.
APA	S. S. Chen,L. L. Tan,Y. X. Teng,B. C. Zhang,&K. Yang.(2013).Study of drug-eluting coating on metal coronary stent.Materials Science & Engineering C-Materials for Biological Applications,33(3),1476-1480.
MLA	S. S. Chen,et al."Study of drug-eluting coating on metal coronary stent".Materials Science & Engineering C-Materials for Biological Applications 33.3(2013):1476-1480.