Effect of nanotube diameters on bioactivity of a multifunctional titanium alloy

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	Effect of nanotube diameters on bioactivity of a multifunctional titanium alloy
	Y. Q. Hao; S. J. Li; Y. L. Hao; Y. K. Zhao; H. J. Ai
	2013
发表期刊	Applied Surface Science
ISSN	0169-4332
卷号	268 页码:44-51
摘要	Ti-24Nb-4Zr-8Sn (abbreviated as Ti2448) is a multifunctional beta type titanium alloy consisting of nontoxic alloying elements and possessing better balanced biomechanical properties of high strength and low elastic modulus. To improve its bioactivity, the anodic oxidation of Ti2448 alloy in neutral electrolyte containing small amounts of NH4F was applied to produce the nanotubes consisting of the amorphous mixed oxides of TiO2, Nb2O5, SnO2 and ZrO2. The in vitro studies of the oestoblast-like MG-63 cells were performed to evaluate the biological behavior of the nanotubes with the outer diameters of 30, 50, 70 and 90 nm in comparison with the polished pure titanium and Ti2448 alloy. The results showed that the smaller diameter of 30 nm promoted the cell adhesion, proliferation and differentiation whereas the larger diameter of 90 nm had the worst cell viability with small spreading area of cytoskeletal actin. Although the nanotubes of Ti2448 alloy consist of the amorphous mixed oxides, it exhibits similar biological behavior with that of the amorphous TiO2 of pure titanium. This suggests that the topography of the amorphous nanotube plays important role on cell response. Additionally, the studies did not detect statistical difference of the bioactivity for the polished pure titanium and Ti2448 alloy. (C) 2012 Elsevier B. V. All rights reserved.
部门归属	[hao, y. q. ; ai, h. j.] china med univ, sch stomatol, dept prosthodont, shenyang 110002, peoples r china. [li, s. j. ; hao, y. l.] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, peoples r china. [zhao, y. k.] china med univ, r&d ctr biotechnol, shenyang 110163, peoples r china. ; ai, hj (reprint author), china med univ, sch stomatol, dept prosthodont, 117 nanjingbei st, shenyang 110002, peoples r china. ; aih0620@yahoo.com.cn
关键词	Anodic Oxidation Nanotube Bioactivity Multifunctional Titanium Alloy Cell Response Surface Biocompatibility Implants Modulus Stress Ti-13nb-13zr Wettability Osteoblasts Coatings
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/71251
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	Y. Q. Hao,S. J. Li,Y. L. Hao,et al. Effect of nanotube diameters on bioactivity of a multifunctional titanium alloy[J]. Applied Surface Science,2013,268:44-51.
APA	Y. Q. Hao,S. J. Li,Y. L. Hao,Y. K. Zhao,&H. J. Ai.(2013).Effect of nanotube diameters on bioactivity of a multifunctional titanium alloy.Applied Surface Science,268,44-51.
MLA	Y. Q. Hao,et al."Effect of nanotube diameters on bioactivity of a multifunctional titanium alloy".Applied Surface Science 268(2013):44-51.