|Tantalum coating on porous Ti6Al4V scaffold using chemical vapor deposition and preliminary biological evaluation|
|X. Li; L. Wang; X. M. Yu; Y. F. Feng; C. T. Wang; K. Yang; D. Su
|Source Publication||Materials Science & Engineering C-Materials for Biological Applications
|Abstract||Porous tantalum (Ta), produced via chemical vapor deposition (CVD) of commercially pure Ta onto a vitreous carbon, is currently available for use in orthopedic applications. However, the relatively high manufacturing cost and the incapability to produce customized implant using medical image data have limited its application to gain widespread acceptance. In this study, Ta film was deposited on porous Ti6Al4V scaffolds using CVD technique. Digital microscopy and scanning electron microscopy indicated that the Ta coating evenly covered the entire scaffold structure. X-ray diffraction analysis showed that the coating consisted of a and beta phases of Ta. Goat mesenchymal stem cells were seeded and cultured on the Ti6Al4V scaffolds with and without coating. The tetrazolium-based colorimetric assay exhibited better cell adhesion and proliferation on Ta-coated scaffolds compared with uncoated scaffolds. The porous scaffolds were subsequently implanted in goats for 12 weeks. Histological analysis revealed similar bone formation around the periphery of the coated and uncoated implants, but bone ingrowth is better within the Ta-coated scaffolds. To demonstrate the ability of producing custom implant for clinical applications via this technology, we designed and fabricated a porous Ti6Al4V scaffold with segmental mandibular shape derived from patient computerized tomography data. (C) 2013 Elsevier B.V. All rights reserved.|
; wang, chengtao
; su, daniel] shanghai jiao tong univ, state key lab mech syst & vibrat, sch mech engn, shanghai 200240, peoples r china. [wang, lin
; feng, yafei] fourth mil med univ, inst orthopaed, xijing hosp, xian 710032, peoples r china. [yu, xiaoming
; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china.
; li, x (reprint author), room 817,bldg a mech engn,800 dongchuan rd, shanghai 200240, peoples r china.
Chemical Vapor Deposition
Electron Beam Melting
X. Li,L. Wang,X. M. Yu,et al. Tantalum coating on porous Ti6Al4V scaffold using chemical vapor deposition and preliminary biological evaluation[J]. Materials Science & Engineering C-Materials for Biological Applications,2013,33(5):2987-2994.
X. Li.,L. Wang.,X. M. Yu.,Y. F. Feng.,C. T. Wang.,...&D. Su.(2013).Tantalum coating on porous Ti6Al4V scaffold using chemical vapor deposition and preliminary biological evaluation.Materials Science & Engineering C-Materials for Biological Applications,33(5),2987-2994.
X. Li,et al."Tantalum coating on porous Ti6Al4V scaffold using chemical vapor deposition and preliminary biological evaluation".Materials Science & Engineering C-Materials for Biological Applications 33.5(2013):2987-2994.
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