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In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model
X. Lin; L. L. Tan; Q. Wang; G. D. Zhang; B. C. Zhang; K. Yang
2013
Source PublicationMaterials Science & Engineering C-Materials for Biological Applications
ISSN0928-4931
Volume33Issue:7Pages:3881-3888
AbstractMagnesium alloys were studied extensively as a class of biodegradable metallic materials for medical applications. In the present study, ZK60 magnesium alloy was considered as a candidate and the micro-arc oxidation (MAO) treatment was adopted in order to reduce the degradation rate of the alloy. The in vivo degradation behaviors and biological compatibilities of ZK60 alloys with and without MAO treatment were studied with a transcortical model in rabbits. The implant and the surrounding bone tissues were characterized by CT, SEM and histological methods at 2,4 and 12 weeks after the implantation. The results demonstrated that both the bare and MAO-coated ZK60 alloys completely degraded within 12 weeks in this animal model. The MAO coating decreased the degradation rate of ZK60 alloy and enhanced the response of the surrounding tissues within the first 2 weeks. After then, an acceleration of the degradation of the MAO-coated ZK60 alloy was observed. It was found that the alloy could be degraded before the complete degradation of the MAO coating, leading to the local peeling off of the coating. An in vivo degradation mechanism of the MAO-coated ZK60 alloy was proposed based on the experimental results. The severe localized degradation caused by the peeling off of the MAO coating was the main reason for the acceleration of the degradation of the MAO-coated ZK60 alloy. (C) 2013 Elsevier B.V. All rights reserved.
description.department[lin, xiao ; tan, lili ; zhang, bingchun ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [wang, qiang ; zhang, guangdao] china med univ, sch stomatol, shenyang 110002, peoples r china. ; yang, k (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china. ; kyang@imr.ac.cn
KeywordMagnesium Alloy Zk60 Micro-arc Oxidation Degradation In Vivo Calcium-phosphate Coatings Osteoclastic Resorption Vitro Degradation Corrosion Behavior Bone Response Implants Biocompatibility Zirconium Silicate Biology
URL查看原文
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/71350
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
X. Lin,L. L. Tan,Q. Wang,et al. In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model[J]. Materials Science & Engineering C-Materials for Biological Applications,2013,33(7):3881-3888.
APA X. Lin,L. L. Tan,Q. Wang,G. D. Zhang,B. C. Zhang,&K. Yang.(2013).In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model.Materials Science & Engineering C-Materials for Biological Applications,33(7),3881-3888.
MLA X. Lin,et al."In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model".Materials Science & Engineering C-Materials for Biological Applications 33.7(2013):3881-3888.
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