Effect of hydrion evolution by polylactic-co-glycolic acid coating on degradation rate of pure iron

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	Effect of hydrion evolution by polylactic-co-glycolic acid coating on degradation rate of pure iron
	J. Y. Wu; X. Lu; L. L. Tan; B. C. Zhang; K. Yang
	2013
发表期刊	Journal of Biomedical Materials Research Part B-Applied Biomaterials
ISSN	1552-4973
卷号	101 期号:7 页码:1222-1232
摘要	For biodegradable iron coronary stents, the major problem is the low degradation rate in body environment. In this study, a new strategy was proposed to increase the degradation rate of iron in vitro. The hydrion evolution was intended to be introduced into the degradation system to increase the degradation rate. To realize this strategy, polylactic-co-glycolic acid (PLGA) was coated onto the surface of pure iron. The degradation process and mechanism of pure iron coated with PLGA were investigated. The results showed that iron coated with PLGA exhibited higher degradation rate in the static immersion test all along. With the degradation of PLGA, the oligomers of PLGA could release abundant H+ which could dissolve the ferrous oxide to make the electrolyte and oxygen to reach the surface of iron again and simultaneity trigger the hydrion evolution at the middle stage of the degradation. The study also revealed that the solution ions failed to permeate the PLGA coating and the deposition of calcium and phosphorus in the degradation layer was inhibited which further enhanced the degradation. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1222-1232, 2013.
部门归属	[wu, jingyao ; lu, xi ; tan, lili ; zhang, bingchun ; yang, ke] chinese acad sci, inst met res, specialized mat & devices div, shenyang 110016, peoples r china. [wu, jingyao] univ sci & technol china, dept mat sci & engn, hefei 230026, peoples r china. [lu, xi] chinese acad sci, grad sch, beijing 100049, peoples r china. ; yang, k (reprint author), chinese acad sci, inst met res, specialized mat & devices div, shenyang 110016, peoples r china. ; kyang@imr.ac.cn
关键词	Biodegradation Coronary Stents Pure Iron Plga Coating In-vitro Degradation Fe-mn Alloys Metallic Biomaterials Cell Viability Stents Solubility Arteries Erosion Design Oxygen
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/71582
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	J. Y. Wu,X. Lu,L. L. Tan,et al. Effect of hydrion evolution by polylactic-co-glycolic acid coating on degradation rate of pure iron[J]. Journal of Biomedical Materials Research Part B-Applied Biomaterials,2013,101(7):1222-1232.
APA	J. Y. Wu,X. Lu,L. L. Tan,B. C. Zhang,&K. Yang.(2013).Effect of hydrion evolution by polylactic-co-glycolic acid coating on degradation rate of pure iron.Journal of Biomedical Materials Research Part B-Applied Biomaterials,101(7),1222-1232.
MLA	J. Y. Wu,et al."Effect of hydrion evolution by polylactic-co-glycolic acid coating on degradation rate of pure iron".Journal of Biomedical Materials Research Part B-Applied Biomaterials 101.7(2013):1222-1232.