|Short-term effect of magnesium implantation on the osteomyelitis modeled animals induced by Staphylococcus aureus|
|J. H. Zeng; L. Ren; Y. J. Yuan; Y. S. Wang; J. B. Zhao; R. M. Zeng; K. Yang; X. F. Mei
|Source Publication||Journal of Materials Science-Materials in Medicine
|Abstract||Pure magnesium (Mg) granules were implanted into the tibial medullary cavity of osteomyelitis modeled animals after debridement, and the animals without implant were taken as the control group. The antibacterial and osteogenic effects on bone tissue during Mg degradation were evaluated through detecting Mg ions, counting bacteria culture in peripheral blood, histology and iconography. The results showed that there was no significant difference for the concentration of serum Mg between the preoperative and postoperative animals within 5 weeks, maintaining in the normal range, and the number of bacteria in bone tissue of the Mg implant group was significantly lower than that of the control group. Mg implantation showed good biocompatibility no harmful to the liver, spleen, kidney and other organs in the modeled animals. In addition, the formation rate of new bone tissues around the implanted Mg was faster, indicating that the degradation of Mg could also promote the osteogenic process with good biocompatibility.|
; yuan, yajiang
; wang, yansong
; zhao, jianbo
; mei, xifan] liaoning med univ, affiliated hosp 1, dept orthoped, guta dist 121000, jinzhou, peoples r china. [ren, ling
; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [zeng, ruming] shenzhen prevent & treatment ctr occupat dis, shenzhen 518001, peoples r china.
; mei, xf (reprint author), liaoning med univ, affiliated hosp 1, dept orthoped, 5-2 renmin st, guta dist 121000, jinzhou, peoples r china.
J. H. Zeng,L. Ren,Y. J. Yuan,et al. Short-term effect of magnesium implantation on the osteomyelitis modeled animals induced by Staphylococcus aureus[J]. Journal of Materials Science-Materials in Medicine,2013,24(10):2405-2416.
J. H. Zeng.,L. Ren.,Y. J. Yuan.,Y. S. Wang.,J. B. Zhao.,...&X. F. Mei.(2013).Short-term effect of magnesium implantation on the osteomyelitis modeled animals induced by Staphylococcus aureus.Journal of Materials Science-Materials in Medicine,24(10),2405-2416.
J. H. Zeng,et al."Short-term effect of magnesium implantation on the osteomyelitis modeled animals induced by Staphylococcus aureus".Journal of Materials Science-Materials in Medicine 24.10(2013):2405-2416.
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