Magnesium Alloy for Repair of Lateral Tibial Plateau Defect in Minipig Model

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	Magnesium Alloy for Repair of Lateral Tibial Plateau Defect in Minipig Model
	Q. Zhang; X. Lin; Z. R. Qi; L. L. Tan; K. Yang; Z. Q. Hu; Y. Wang
	2013
发表期刊	Journal of Materials Science & Technology
ISSN	1005-0302
卷号	29 期号:6 页码:539-544
摘要	Bone graft substitutes are widely-studied as alternatives to bone grafts in the clinic. The currently available products are mostly ceramics and polymers. Considerable progress has been made in the study of the biodegradable magnesium alloys, which possess the necessary attributions of a suitable substitute, including an excellent mechanical property. In the present study, a minipig model of a lateral tibial plateau defect was used to evaluate the effectiveness of a magnesium alloy in the repair of a critical-sized defect. The micro-arc oxidation (MAO)-coated ZK60 alloy tablets and medical-grade calcium sulfate pellets were used as the test and control materials, respectively. Bone morphology was monitored by computed tomography after the implantation for 2 and 4 months. It was found that the bone morphology in minipigs following magnesium treatment was similar to that of the normal bone, whereas an abnormal and concave morphology was displayed following the calcium sulfate treatment. The average bone healing rate for the magnesium-treated defects was higher than that of the calcium sulfate-treated defects at the first 4 months following the implantation. Overall, magnesium treatment appeared to improve the defect repair as compared with the calcium sulfate treatment. Thus, the MAO-coated ZK60 alloy appears to be a useful biocompatible bone graft substitute, and further research on its biological activity in vivo is needed.
部门归属	[zhang, qiang ; qi, zhengrong ; wang, yan] chinese peoples liberat army gen hosp, dept orthopaed, beijing 100853, peoples r china. [lin, xiao ; tan, lili ; yang, ke ; hu, zhuangqi] chinese acad sci, inst met res, shenyang 110016, peoples r china. ; tan, ll (reprint author), chinese acad sci, inst met res, shenyang 110016, peoples r china. ; lltan@imr.ac.cn ; 301yanwang@gmail.com
关键词	Biocompatibility Biodegradable Magnesium Bone Graft Substitute Tibial Plateau Defect In-vivo Bone
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语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/71689
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	Q. Zhang,X. Lin,Z. R. Qi,et al. Magnesium Alloy for Repair of Lateral Tibial Plateau Defect in Minipig Model[J]. Journal of Materials Science & Technology,2013,29(6):539-544.
APA	Q. Zhang.,X. Lin.,Z. R. Qi.,L. L. Tan.,K. Yang.,...&Y. Wang.(2013).Magnesium Alloy for Repair of Lateral Tibial Plateau Defect in Minipig Model.Journal of Materials Science & Technology,29(6),539-544.
MLA	Q. Zhang,et al."Magnesium Alloy for Repair of Lateral Tibial Plateau Defect in Minipig Model".Journal of Materials Science & Technology 29.6(2013):539-544.