The antibacterial properties and biocompatibility of a Ti-Cu sintered alloy for biomedical application

IMR OpenIR

	The antibacterial properties and biocompatibility of a Ti-Cu sintered alloy for biomedical application
	J. Liu; X. X. Zhang; H. Y. Wang; F. B. Li; M. Q. Li; K. Yang; E. L. Zhang
	2014
发表期刊	Biomedical Materials
ISSN	1748-6041
卷号	9 期号:2
摘要	The antibacterial activity, the cytotoxicity and the cell function of a sintered Ti-10 wt% Cu alloy were investigated in order to assess the suitability of the alloy for biomedical application. The antibacterial activity of the alloy was investigated by a plate-count method and the cytotoxicity was studied by examining the MG63 cell response by CCK8 assessment. The cell function was monitored by measuring the AKP activity. The Cu ion released from the Ti-Cu alloy was also measured by an inductively coupled plasma spectrometer at different immersion durations. The results show that the antibacterial rates of the alloy against Escherichia coli and Staphylococcus aureus increase with an increase in the incubation duration. After 7 h of incubation, the alloy showed an antibacterial rate of 91.66% against S. aureus and 99.01% against E. coli. With a further extension of incubation time to 24 h, the antibacterial rate increased to 100% against S. aureus and 99.93% against E. coli. No cytotoxicity was observed on the alloy by a CKK8 test during three days of incubation in comparison with commercially available pure titanium (cp-Ti). AKP test results showed a significantly high AKP value (p = 0.001 < 0.01) on the Ti-Cu alloy on day 1. The Cu ion release was thought to contribute to the strong antibacterial property, but the Cu ion did not lead to cell cytotoxicity. Strong antibacterial activity and good cell biocompatibility suggest that the Ti-Cu alloy could reduce bacterial infection and have a potential application as an implant material.
部门归属	[liu, jie ; zhang, xinxin ; wang, hongying ; li, fangbing ; li, muqin ; zhang, erlin] jiamusi univ, jiamusi 154007, peoples r china. [liu, jie] qingdao univ, coll med, affiliated hosp, dept prosthodont, qingdao 266003, peoples r china. [yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [zhang, erlin] northeastern univ, educ minist china, key lab anisotropy & texture mat, shenyang 110819, peoples r china. ; zhang, el (reprint author), jiamusi univ, jiamusi 154007, peoples r china. ; zhangel@atm.neu.edu.cn
关键词	Biocompatibility Antibacterial Activity Ti-cu Alloy Akp Corrosion Property Implant Materials Osteoblast-like Cells Alkaline-phosphatase Activity In-vitro Titanium Surface Hydroxyapatite Coatings Ion-implantation Copper Metal Zinc Proliferation
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/72556
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	J. Liu,X. X. Zhang,H. Y. Wang,et al. The antibacterial properties and biocompatibility of a Ti-Cu sintered alloy for biomedical application[J]. Biomedical Materials,2014,9(2).
APA	J. Liu.,X. X. Zhang.,H. Y. Wang.,F. B. Li.,M. Q. Li.,...&E. L. Zhang.(2014).The antibacterial properties and biocompatibility of a Ti-Cu sintered alloy for biomedical application.Biomedical Materials,9(2).
MLA	J. Liu,et al."The antibacterial properties and biocompatibility of a Ti-Cu sintered alloy for biomedical application".Biomedical Materials 9.2(2014).