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Comparison of degradation behavior and the associated bone response of ZK60 and PLLA in vivo
Z. R. Qi; Q. Zhang; L. L. Tan; X. Lin; Y. Yin; X. L. Wang; K. Yang; Y. Wang
2014
Source PublicationJournal of Biomedical Materials Research Part A
ISSN1549-3296
Volume102Issue:5Pages:1255-1263
AbstractThe aim of this study was to investigate whether ZK60, an extruded magnesium alloy, reacts in vivo with an appropriate host response, and to investigate how microarc oxidation treatment influences this in vivo corrosion behavior. Twelve cylinders were machined from as-extruded ZK60, with six cylinders treated with MAO and six left untreated; poly-l-lactic acid pins were used as a control to compare biocompatibility. These cylinders were implanted into the right distal femur of mice along the transepicondylar axis from the medial condyle. Microcomputerized tomography was used to quantitatively analyze corrosion in a nondestructive manner in vivo and the corrosion rate was calculated based on the volume measurements of the residual implants. The physiological response of the rats postimplantation was obtained by clinical observation and blood biochemical analysis. Histological analyses of the soft tissue around the implants were used to assess bone response in relation to the implants. The results obtained clearly indicate that the untreated ZK60 alloy showed high degradation rates in vivo, and that MAO treatment had a significant but unsatisfying effect on protecting the implant from further corrosion. Compared with PLLA, the ZK60 alloy showed good osteoconductivity and osteoinductivity, and, according to biochemical indicators, had good biocompatibility in vivo. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1255-1263, 2014.
description.department[qi, zheng-rong ; zhang, qiang ; yin, yi ; wang, xiu-li ; wang, yan] chinese peoples liberat army gen hosp, dept orthoped, beijing, peoples r china. [tan, li-li ; lin, xiao ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. ; wang, y (reprint author), chinese peoples liberat army gen hosp, dept orthoped, beijing, peoples r china. ; 301yanwang@gmail.com
KeywordBone Response In Vivo Biocompatibility Magnesium Alloy Degradation Magnesium Alloys Vitro Corrosion Oxidation Zn Biocompatibility Biomaterials Mechanisms
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Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/72898
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Z. R. Qi,Q. Zhang,L. L. Tan,et al. Comparison of degradation behavior and the associated bone response of ZK60 and PLLA in vivo[J]. Journal of Biomedical Materials Research Part A,2014,102(5):1255-1263.
APA Z. R. Qi.,Q. Zhang.,L. L. Tan.,X. Lin.,Y. Yin.,...&Y. Wang.(2014).Comparison of degradation behavior and the associated bone response of ZK60 and PLLA in vivo.Journal of Biomedical Materials Research Part A,102(5),1255-1263.
MLA Z. R. Qi,et al."Comparison of degradation behavior and the associated bone response of ZK60 and PLLA in vivo".Journal of Biomedical Materials Research Part A 102.5(2014):1255-1263.
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