In vitro cytocompatibility and corrosion resistance of zinc-doped hydroxyapatite coatings on a titanium substrate

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	In vitro cytocompatibility and corrosion resistance of zinc-doped hydroxyapatite coatings on a titanium substrate
	Q. Q. Ding; X. J. Zhang; Y. Huang; Y. J. Yan; X. F. Pang
	2015
发表期刊	Journal of Materials Science
ISSN	0022-2461
卷号	50 期号:1 页码:189-202
摘要	To improve biocompatibility and corrosion resistance during the initial implantation stage, zinc-substituted hydroxyapatite (ZnHAp) coating was fabricated on pure titanium by the electrolytic deposition method. The morphology, microstructure and chemical composition of the coating were investigated by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray analysis and Fourier transform infrared spectroscopy. The prepared ZnHAp crystals were calcium deficient and were carbonated owing to the incorporation of some Zn2+. This incorporation of Zn2+ into the HAp significantly reduced porosity and caused the coating to become noticeably denser. In addition, the Zn2+ ions were homogeneously distributed in the coating. The potentiodynamic polarisation test revealed that the ZnHAp-coated surface showed superior corrosion resistance over that of the HAp-coated surface and bare Ti. The in vitro bioactivity was evaluated in a simulated body fluid, which revealed that the ZnHAp coating can rapidly induce bone-like apatite formation of nuclear and growth features. In addition, the cell response tests showed that the MC3T3-E1 cells on the ZnHAp coating clearly enhanced the in vitro cytocompatibility of Ti compared with the same cells on HAp coating. ZnHAp coating was thus beneficial for improving biocompatibility.
部门归属	[ding, qiongqiong ; yan, yajing ; pang, xiaofeng] univ elect sci & technol china, inst life sci & technol, chengdu 610054, peoples r china. [zhang, xuejiao] hebei north univ, med informat engn, zhangjiakou 075000, peoples r china. [huang, yong] hebei north univ, coll lab med, zhangjiakou 075000, peoples r china. [pang, xiaofeng] chinese acad sci, int ctr mat phys, shenyang 110015, peoples r china. ; pang, xf (reprint author), univ elect sci & technol china, inst life sci & technol, chengdu 610054, peoples r china. ; huangyong1@aliyun.com ; xfpang@aliyun.com
关键词	316l Stainless-steel Calcium-phosphate Magnesium Alloy Electrophoretic Deposition Biomedical Applications Cell-proliferation Composite Implants Nanoparticles Electrodeposition
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/73213
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	Q. Q. Ding,X. J. Zhang,Y. Huang,et al. In vitro cytocompatibility and corrosion resistance of zinc-doped hydroxyapatite coatings on a titanium substrate[J]. Journal of Materials Science,2015,50(1):189-202.
APA	Q. Q. Ding,X. J. Zhang,Y. Huang,Y. J. Yan,&X. F. Pang.(2015).In vitro cytocompatibility and corrosion resistance of zinc-doped hydroxyapatite coatings on a titanium substrate.Journal of Materials Science,50(1),189-202.
MLA	Q. Q. Ding,et al."In vitro cytocompatibility and corrosion resistance of zinc-doped hydroxyapatite coatings on a titanium substrate".Journal of Materials Science 50.1(2015):189-202.