Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium

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	Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium
	M. Li; L. Ren; L. H. Li; P. He; G. B. Lan; Y. Zhang; K. Yang
	2014
发表期刊	Journal of Materials Science & Technology
ISSN	1005-0302
卷号	30 期号:9 页码:888-893
摘要	Biocompatible and biodegradable magnesium (Mg) based metals have attracted great interest for use in orthopedic implants and devices. Based on our previous study that Mg with and without micro-arc oxidation (MAO) coating showed obvious cytotoxic effect on tumor cells due to the increase of pH value during the degradation of Mg, this study further evaluated the cytotoxic effect of Mg and MAO coated Mg on osteosarcoma (MG-63) cells by analyzing the cell adhesion, morphology and number through observation of scanning electron microscope, as well as live/dead staining, lactate dehydrogenase (LDH) activity and 4, 6-diamidino-2-phenylindole (DAPI) assay. The results indicated that, compared to titanium, Mg could strongly inhibit the cell adherence, morphology and number of MG-63 on the surface of the naked Mg, whereas the MAO coated Mg showed relative weak cytotoxic effect on MG-63 cells, expecting that magnesium based metals with suitable coating can be designed to be applied as tumor prosthesis in the clinical practice.
部门归属	[li, mei ; li, lihua ; he, peng ; lan, guobo ; zhang, yu] guangzhou gen hosp guangzhou mil command, orthoped hosp, guangzhou 510010, guangdong, peoples r china. [ren, ling ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. ; zhang, y (reprint author), guangzhou gen hosp guangzhou mil command, orthoped hosp, guangzhou 510010, guangdong, peoples r china. ; luck_2001@126.com ; kyang@imr.ac.cn
关键词	Magnesium Biodegradation Osteosarcoma Cytotoxicity In-vitro Bone Mechanisms Scaffolds Adhesion Implants Alloy
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/73276
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	M. Li,L. Ren,L. H. Li,et al. Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium[J]. Journal of Materials Science & Technology,2014,30(9):888-893.
APA	M. Li.,L. Ren.,L. H. Li.,P. He.,G. B. Lan.,...&K. Yang.(2014).Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium.Journal of Materials Science & Technology,30(9),888-893.
MLA	M. Li,et al."Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium".Journal of Materials Science & Technology 30.9(2014):888-893.