MRI-compatible Nb-60Ta-2Zr alloy used for vascular stents: Haemocompatibility and its correlation with protein adsorption

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	MRI-compatible Nb-60Ta-2Zr alloy used for vascular stents: Haemocompatibility and its correlation with protein adsorption
	X. M. Li; H. Z. Li; S. P. Wang; H. M. Huang; H. H. Huang; H. J. Ai; J. Xu
	2014
发表期刊	Materials Science & Engineering C-Materials for Biological Applications
ISSN	0928-4931
卷号	42 页码:385-395
摘要	Nb-60Ta-2Zr is a newly developed MRI-compatible alloy used for vascular stents. In this work, its haemocompatibility was investigated, including platelet adhesion (lactate dehydrogenase activity), platelet activation (P-selectin expression), coagulation and haemolysis. For comparison, parallel assessments for these factors were performed for the niobium, tantalum, 316L stainless steel (316L SS) and L605 Co-Cr alloy (L605). In addition, albumin and fibrinogen were selected to examine the correlation of protein adsorption with platelet adhesion and metal surface properties. The propensity for platelet adhesion and activation on the Nb-60Ta-2Zr alloy was at nearly the same level as that for Nb and Ta but was slightly less than those of 316L SS and L605. The mitigated platelet adhesion and activation of the Nb-60Ta-2Zr alloy is associated with its decreased adsorption of fibrinogen. The Nb-60Ta-2Zr alloy has a longer clotting time and exhibits significantly superior thromboresistance than 316L SS and L605. Moreover, the haemolysis rate of the Nb-60Ta-2Zr alloy satisfies the bin-safety requirement of the ISO 10993-4 standard. The favourable haemocompatiblity of the Nb-60Ta-2Zr alloy provides evidence of its good biocompatibility and of its suitability as a candidate stent material. (C) 2014 Elsevier B.V. All rights reserved.
部门归属	[li, xiu-mei ; ai, hong-jun] china med univ, sch stomatol, shenyang 110002, peoples r china. [li, hui-zhe ; wang, shao-ping ; xu, jian] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, peoples r china. [huang, hsun-miao ; huang, her-hsiung] natl yang ming univ, dept dent, biomat & elect lab, taipei 112, taiwan. ; ai, hj (reprint author), china med univ, sch stomatol, 117 nanjing north st, shenyang 110002, peoples r china. ; aih0620@yahoo.com.cn ; jianxu@imr.ac.cn
关键词	Haemocompatibility Platelet Adhesion Protein Adsorption Niobium Stent Stainless-steel In-vitro Surface Wettability Biomaterial Surfaces Blood-compatibility Platelet-adhesion Nanometer-scale Serum-albumin Whole-blood Niti Alloys
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/73285
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	X. M. Li,H. Z. Li,S. P. Wang,et al. MRI-compatible Nb-60Ta-2Zr alloy used for vascular stents: Haemocompatibility and its correlation with protein adsorption[J]. Materials Science & Engineering C-Materials for Biological Applications,2014,42:385-395.
APA	X. M. Li.,H. Z. Li.,S. P. Wang.,H. M. Huang.,H. H. Huang.,...&J. Xu.(2014).MRI-compatible Nb-60Ta-2Zr alloy used for vascular stents: Haemocompatibility and its correlation with protein adsorption.Materials Science & Engineering C-Materials for Biological Applications,42,385-395.
MLA	X. M. Li,et al."MRI-compatible Nb-60Ta-2Zr alloy used for vascular stents: Haemocompatibility and its correlation with protein adsorption".Materials Science & Engineering C-Materials for Biological Applications 42(2014):385-395.