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Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells
A. Mastrofrancesco; M. Alfe; E. Rosato; V. Gargiulo; C. Beatrice; G. Di Blasio; B. Zhang; D. S. Su; M. Picardo; S. Fiorito
2014
Source PublicationJournal of Immunology Research
ISSN2314-8861
AbstractAutoimmune diseases are complex disorders of unknown etiology thought to result from interactions between genetic and environmental factors. We aimed to verify whether environmental pollution from diesel engine exhaust nanoparticulate (DEP) of actually operating vehicles could play a role in the development of a rare immune-mediated disease, systemic sclerosis (SSc), in which the pathogenetic role of environment has been highlighted. The effects of carbon-based nanoparticulate collected at the exhaust of newer (Euro 5) and older (Euro 4) diesel engines on SSc skin keratinocytes and fibroblasts were evaluated in vitro by assessing the mRNA expression of inflammatory cytokines (IL-1 alpha, IL-6, IL-8, and TNF-alpha) and fibroblast chemical mediators (metalloproteases 2, 3, 7, 9, and 12; collagen types I and III; VEGF). DEP was shown to stimulate cytokine gene expression at a higher extent in SSc keratinocytes versus normal cells. Moreover, them RNA gene expression of all MMPs, collagen types, and VEGF genes was significantly higher in untreated SSc fibroblasts versus controls. Euro 5 particle exposure increased the mRNA expression of MMP-2, -7, and -9 in SSc fibroblasts in a dose dependent manner and only at the highest concentration in normal cells. We suggest that environmental DEP could trigger the development of SSc acting on genetically hyperreactive cell systems.
description.department[mastrofrancesco, a. ; picardo, m.] ist dermatol s maria & s gallicano, lab fisiopatol cutanea, i-00144 rome, italy. [alfe, m. ; gargiulo, v.] cnr, ist ric combust, i-80125 naples, italy. [rosato, e. ; fiorito, s.] univ roma la sapienza, cnr, dipartimento med clin, i-00185 rome, italy. [beatrice, c. ; di blasio, g.] ist motori, i-80125 naples, italy. [zhang, b. ; su, d. s.] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, peoples r china. ; fiorito, s (reprint author), univ roma la sapienza, cnr, dipartimento med clin, viale univ 37, i-00185 rome, italy. ; silvana.fiorito@uniroma1.it
KeywordSystemic-sclerosis Correlation Autoimmune-diseases Matrix Metalloproteinases Lupus-erythematosus Air-pollution Geoepidemiology Fibroblasts Mechanisms Expression Exposure
URL查看原文
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/73340
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
A. Mastrofrancesco,M. Alfe,E. Rosato,et al. Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells[J]. Journal of Immunology Research,2014.
APA A. Mastrofrancesco.,M. Alfe.,E. Rosato.,V. Gargiulo.,C. Beatrice.,...&S. Fiorito.(2014).Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells.Journal of Immunology Research.
MLA A. Mastrofrancesco,et al."Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells".Journal of Immunology Research (2014).
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