Fabrication and evaluation of bioresorbable PLLA/magnesium and PLLA/magnesium fluoride hybrid composites for orthopedic implants

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	Fabrication and evaluation of bioresorbable PLLA/magnesium and PLLA/magnesium fluoride hybrid composites for orthopedic implants
	P. Wan; C. Yuan; L. L. Tan; Q. Li; K. Yang
	2014
发表期刊	Composites Science and Technology
ISSN	0266-3538
卷号	98 页码:36-43
摘要	Polymers, such as poly-L-lactide (PLLA) were the first materials to be used as commercial biodegradable and bioresorbable implant materials. However, the limitations were focused on low mechanical properties and acid degradation by-products which were concerned as the source of inflammation. In this work, hybrid composites incorporated PLLA with 3-7 wt% magnesium and magnesium fluoride particles were developed to overcome drawbacks mentioned above as novel bioresorbable orthopedic implants. The morphology, mechanical and thermal properties, in vitro degradation and cytotoxicity assessment were analyzed by SEM, DSC, UTM, pH value monitoring and MIT. It was found that the tensile strength was slightly decreased with addition of Mg particles. The tensile fracture morphologies indicated that the interface adhesion between Mg particles and PLLA matrix could be contributed to the influence on mechanism property. The addition of Mg and MgF2 into PLLA was effective in neutralizing the acid environment caused by degradation by-products, which was reflected by a close pH value to body fluid. Moreover, cell viability showed better cytocompatibility of composites with the beneficial Mg ions release. Therefore, PLLA/magnesium and PLLA/magnesium fluoride hybrid composites had a promising potential for orthopedic implant application. (C) 2014 Elsevier Ltd. All rights reserved.
部门归属	[wan, peng ; tan, lili ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [yuan, chen ; li, qi] liaoning univ, coll chem, shenyang 110036, peoples r china. ; wan, p (reprint author), chinese acad sci, inst met res, shenyang 110016, peoples r china. ; pwan@imr.ac.cn
关键词	Polymer-matrix Composites Corrosion Damage Mechanics Scanning Electron Microscopy Injection Molding Magnesium Bone Poly(L-lactide) Biocompatibility Scaffolds Corrosion Acid
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/73396
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	P. Wan,C. Yuan,L. L. Tan,et al. Fabrication and evaluation of bioresorbable PLLA/magnesium and PLLA/magnesium fluoride hybrid composites for orthopedic implants[J]. Composites Science and Technology,2014,98:36-43.
APA	P. Wan,C. Yuan,L. L. Tan,Q. Li,&K. Yang.(2014).Fabrication and evaluation of bioresorbable PLLA/magnesium and PLLA/magnesium fluoride hybrid composites for orthopedic implants.Composites Science and Technology,98,36-43.
MLA	P. Wan,et al."Fabrication and evaluation of bioresorbable PLLA/magnesium and PLLA/magnesium fluoride hybrid composites for orthopedic implants".Composites Science and Technology 98(2014):36-43.