Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate

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	Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate
	Y.; Zhang Huang, X. J.; Zhao, R. L.; Mao, H. H.; Yan, Y. J.; Pang, X. F.
	2015
发表期刊	Journal of Materials Science
ISSN	0022-2461
卷号	50 期号:4 页码:1688-1700
摘要	This work elucidated the antibacterial efficacy, corrosion resistance, and cytotoxicity of electroplated copper-substituted hydroxyapatite (CuHAP) coating on titanium (Ti). The fabricated CuHAP coatings were characterized by scanning electron microscopy, energy-dispersive X-ray analysis spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction studies. The CuHAP coating had needle-like apatite crystals, the doping of Cu2+ into HAP reduced porosity, and the coating became denser. The CuHAP crystals were carbonated with a few of Cu2+ incorporation (about 0.80 wt%). The Cu2+ ions were homogenously deposited into HAP films. Potentiodynamic polarisation test revealed that the CuHAP coating provided good barrier characteristics and achieved superior corrosion protection for Ti substrates. The in vitro antibacterial activity of as-prepared CuHAP coating was evaluated against Escherichia coli and was found to be effectively high against bacterial colonization. Bioactivity test conducted by soaking the coatings in simulated body fluid demonstrated that CuHAP coating can quickly induce bone-like apatite nucleation and growth. In vitro biocompatibility tests, MTT, were employed to assess the cytotoxicity of CuHAP coating with osteoblast-like MC3T3-E1 cells. The obtained HAP coating doped with a low content of Cu2+ exhibited good cytocompatibility and had no toxicity toward MC3T3-E1.
部门归属	[huang, yong ; zhang, xuejiao] hebei north univ, coll lab med, zhangjiakou 075000, peoples r china. [huang, yong ; zhao, ranlin ; mao, huanhuan ; yan, yajing ; pang, xiaofeng] univ elect sci & technol china, inst life sci & technol, chengdu 610054, peoples r china. [pang, xiaofeng] chinese acad sci, int ctr mat phys, shenyang 110015, peoples r china. ; huang, y (reprint author), univ elect sci & technol china, inst life sci & technol, chengdu 610054, peoples r china. ; xfpang@aliyun.com
关键词	Doped Hydroxyapatite In-vitro Electrophoretic Deposition Carbon/carbon Composites Biomedical Applications Antimicrobial Activity Osteoblastic Cells Stainless-steel Bone Bioactivity
URL	查看原文
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/73824
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	Y.,Zhang Huang, X. J.,Zhao, R. L.,et al. Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate[J]. Journal of Materials Science,2015,50(4):1688-1700.
APA	Y.,Zhang Huang, X. J.,Zhao, R. L.,Mao, H. H.,Yan, Y. J.,&Pang, X. F..(2015).Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate.Journal of Materials Science,50(4),1688-1700.
MLA	Y.,et al."Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate".Journal of Materials Science 50.4(2015):1688-1700.