Cu-bearing steel reduce inflammation after stent implantation

IMR OpenIR

	Cu-bearing steel reduce inflammation after stent implantation
	J. Z.; Ren Li, L.; Zhang, S. Y.; Ren, G. G.; Yang, K.
	2015
发表期刊	Journal of Materials Science-Materials in Medicine
ISSN	0957-4530
卷号	26 期号:2
摘要	Copper (Cu)-bearing stainless steel with release of Cu2+ ions is a novel material for coronary stents that could reduce the in-stent restenosis after the stent implantation. The inflammation has been recently recognized as an important factor to smooth muscle cells proliferation, thrombosis, and hence the restenosis post-angioplasty. The objective of this study is to further investigate the effect and relevant mechanism of Cu-bearing stainless steel (316L-Cu SS) on the inflammation reaction after stent implantation. The results demonstrated that, compared with commercial coronary stent material (316L SS), 316L-Cu SS could inhibit the inflammation caused by endothelial dysfunction through blockading the inflammatory factors (TNF-alpha, IL-1 beta, 6, 8), which would then reduce the recruitment and infiltration of leukocytes, rather than have direct effect on leukocytes. This finding further explained the reduction effect of 316L-Cu SS on in-stent restenosis from a novel view.
部门归属	[li, jinzhao] liaoning med coll, affiliated hosp 1, jinzhou 121000, peoples r china. [ren, ling ; zhang, shuyuan ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [ren, guogang] univ hertfordshire, hatfield al10 9ab, herts, england. ; ren, l (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china. ; medicaldoctor33@sina.com ; lren@imr.ac.cn ; zhangsy@imr.ac.cn ; g.g.ren@herts.ac.uk ; kyang@imr.ac.cn
关键词	Balloon Catheter Carotid-artery Restenosis Rabbit Responses Sequence
URL	查看原文
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/73840
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	J. Z.,Ren Li, L.,Zhang, S. Y.,et al. Cu-bearing steel reduce inflammation after stent implantation[J]. Journal of Materials Science-Materials in Medicine,2015,26(2).
APA	J. Z.,Ren Li, L.,Zhang, S. Y.,Ren, G. G.,&Yang, K..(2015).Cu-bearing steel reduce inflammation after stent implantation.Journal of Materials Science-Materials in Medicine,26(2).
MLA	J. Z.,et al."Cu-bearing steel reduce inflammation after stent implantation".Journal of Materials Science-Materials in Medicine 26.2(2015).