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Drug delivery property, antibacterial performance and cytocompatibility of gentamicin loaded poly(lactic-co-glycolic acid) coating on porous magnesium scaffold
Y.; Liu Li, L.; Qu, X.; Ren, L.; Dai, K.
2015
Source PublicationMaterials Technology
ISSN1066-7857
Volume30Issue:B2Pages:B96-B103
AbstractImplant associated infection remains a difficult medical problem in orthopaedic surgery. Here, we report on the fabrication of gentamicin loaded poly(lactic-co-glycolic acid) (PLGA) coating on porous magnesium scaffold (Gent-PLGA-Mg) for use as a type of controlled antibiotic delivery system bone scaffolds to achieve the sustained release of antibiotics in the local sites of bone defects. The drug loaded PLGA coating of Mg scaffold enable higher drug loading efficiency (28-33%) than non-coating gentamicin loaded Mg scaffold (Gent-Mg) (2-3%). The Gent-PLGA-Mg exhibited sustained drug release for more than 14 days, and this controlled release of gentamicin significantly inhibited bacterial adhesion and prevented biofilm formation by Staphylococcus aureus (ATCC25923) and Staphylococcus epidermidis (ATCC35984). Biocompatibility tests with human bone marrow stromal cells indicated that PLGA-Mg had better biocompatibility than Mg. Therefore, Gent-PLGA-Mg is potential to be used as a controlled drug delivery system bone scaffolds to prevent and/or treat orthopaedic peri-implant infections.
description.department[li, y. ; qu, x. ; dai, k.] shanghai jiao tong univ, sch med, shanghai key lab orthopaed implants, shanghai peoples hosp 9,dept orthopaed surg, shanghai 200011, peoples r china. [liu, l.] shanghai jiao tong univ, sch med, shanghai peoples hosp 9, dept plast & reconstruct surg, shanghai 200011, peoples r china. [ren, l.] chinese acad sci, inst met res, shenyang 110016, peoples r china. ; li, y (reprint author), shanghai jiao tong univ, sch med, shanghai key lab orthopaed implants, shanghai peoples hosp 9,dept orthopaed surg, shanghai 200011, peoples r china. ; xinhua_qu@126.com ; lren@imr.ac.cn ; krdai@163.com
KeywordPorous Magnesium Scaffold Plga Drug Delivery System Bactericidal Activity Biocompatibility Mesoporous Bioactive Glass Staphylococcus-aureus In-vitro Release Properties Biofilm Formation Titanium Differentiation Osteomyelitis Implantation Infections
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/73849
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Y.,Liu Li, L.,Qu, X.,et al. Drug delivery property, antibacterial performance and cytocompatibility of gentamicin loaded poly(lactic-co-glycolic acid) coating on porous magnesium scaffold[J]. Materials Technology,2015,30(B2):B96-B103.
APA Y.,Liu Li, L.,Qu, X.,Ren, L.,&Dai, K..(2015).Drug delivery property, antibacterial performance and cytocompatibility of gentamicin loaded poly(lactic-co-glycolic acid) coating on porous magnesium scaffold.Materials Technology,30(B2),B96-B103.
MLA Y.,et al."Drug delivery property, antibacterial performance and cytocompatibility of gentamicin loaded poly(lactic-co-glycolic acid) coating on porous magnesium scaffold".Materials Technology 30.B2(2015):B96-B103.
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