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A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration
Zhang, Shanchuan; Yang, Ke; Cui, Fuzhai; Jiang, Yi; E, Lingling; Xu, Baohua; Liu, Hongchen; baohuaxuu@163.com; hongchenldr@163.com
2015
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6133
Pages-
AbstractObjective. A novel injectable magnesium/calcium sulfate hemihydrate (Mg/CSH) composite with improved properties was reported here. Methods. Composition, setting time, injectability, compressive strength, and bioactivity in simulated body fluid (SBF) of the Mg/CSH composite were evaluated. Furthermore, the cellular responses of canine bone marrow stromal cells (cBMSCs) and bone formation capacity after the implantation of Mg/CSH in tibia defects of canine were investigated. Results. Mg/CSH possessed a prolonged setting time and markedly improved injectability and mechanical property (p < 0.05). Mg/CSH samples showed better degradability than CSH in SBF after 21 days of soaking (p < 0.05). Moreover, the degrees of cell attachment, proliferation, and capability of osteogenic differentiation on the Mg/CSH specimens were higher than those on CSH, without significant cytotoxicity and with the increased proliferation index, ALP activity, and expression levels of integrin beta(1) and Coll I in cBMSCs (p < 0.05). Mg/CSH enhanced the efficiency of new bone formation at the tibia defect area, including the significantly elevated bone mineral density, bone area fraction, and Coll I expression level (p < 0.05). Conclusions. The results implied that this new injectable bone scaffold exhibited promising prospects for bone repair and had a great potential in bone tissue engineering.
description.department[zhang, shanchuan ; xu, baohua] china japan friendship hosp, ctr stomatol, beijing 100029, peoples r china ; [zhang, shanchuan ; e, lingling ; liu, hongchen] chinese peoples liberat army gen hosp, inst stomatol, beijing 100853, peoples r china ; [yang, ke] chinese acad sci, inst met res, specialized mat & devices div, shenyang 110016, peoples r china ; [cui, fuzhai] tsinghua univ, adv mat lab, beijing 100084, peoples r china ; [jiang, yi] chinese peoples liberat army gen hosp, dept geriatr dent, beijing 100853, peoples r china
Funding OrganizationState Natural Science Fund, China [81200819]; China Postdoctoral Science Foundation [2013T60943, 2012M512121]
Indexed Bysci
Language英语
WOS IDWOS:000356260400001
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/74596
Collection中国科学院金属研究所
Corresponding Authorbaohuaxuu@163.com; hongchenldr@163.com
Recommended Citation
GB/T 7714
Zhang, Shanchuan,Yang, Ke,Cui, Fuzhai,et al. A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration[J]. BIOMED RESEARCH INTERNATIONAL,2015:-.
APA Zhang, Shanchuan.,Yang, Ke.,Cui, Fuzhai.,Jiang, Yi.,E, Lingling.,...&hongchenldr@163.com.(2015).A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration.BIOMED RESEARCH INTERNATIONAL,-.
MLA Zhang, Shanchuan,et al."A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration".BIOMED RESEARCH INTERNATIONAL (2015):-.
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