Cytocompatibility and Hemolysis of AZ31B Magnesium Alloy with Si-containing Coating

IMR OpenIR

	Cytocompatibility and Hemolysis of AZ31B Magnesium Alloy with Si-containing Coating
	Wang, Qiang; Tan, Lili; Yang, Ke; mfqwang@163.com
	2015
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	31 期号:8 页码:845-851
摘要	In the present study, a Si-containing coating was fabricated on AZ31B Mg alloy. Cytocompatibility of the coated alloy was evaluated by both indirect and direct contact methods, respectively. Effects of a number of incubation variables on the sensitivity and reproducibility of the hemolysis test were also examined by using positively and negatively responding biomaterials. Cytocompatibility testing results indicated that cell condition, cell adherence, cell proliferation and extracellular matrix secretion of the coated alloy were improved compared with those of the uncoated alloy for different extraction and co-culture time. The hemolysis test suggested that hemolysis testing conditions were critical to determine the hemolysis of the alloy. It was also found that 1 day in vitro degradation of the uncoated AZ31B alloy had no destructive effect on erythrocyte. As for the coated AZ31B alloy at any time point, the hemolysis rate was much lower than 5%, the safe value for biomaterials. These in vitro experimental results indicate that the Si-containing coating is effective to improve the cytocompatibility and hemolysis behaviors of AZ31B alloy during its degradation. Copyright (C) 2015, The editorial office of Journal of Materials Science & Technology. Published by Elsevier Limited. All rights reserved.
部门归属	[wang, qiang] china med univ, sch stomatol, shenyang 110002, peoples r china ; [tan, lili ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china
关键词	Magnesium Alloys Biodegradable Cytocompatibility Hemolysis
资助者	National Basic Research Program [2012CB619101]; National Natural Science Foundation of China [30970715]
收录类别	sci
语种	英语
WOS记录号	WOS:000359495200011
引用统计	被引频次：49[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/74703
专题	中国科学院金属研究所
通讯作者	mfqwang@163.com
推荐引用方式 GB/T 7714	Wang, Qiang,Tan, Lili,Yang, Ke,et al. Cytocompatibility and Hemolysis of AZ31B Magnesium Alloy with Si-containing Coating[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2015,31(8):845-851.
APA	Wang, Qiang,Tan, Lili,Yang, Ke,&mfqwang@163.com.(2015).Cytocompatibility and Hemolysis of AZ31B Magnesium Alloy with Si-containing Coating.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,31(8),845-851.
MLA	Wang, Qiang,et al."Cytocompatibility and Hemolysis of AZ31B Magnesium Alloy with Si-containing Coating".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 31.8(2015):845-851.