Direct Methylation of Amines with Carbon Dioxide and Molecular Hydrogen using Supported Gold Catalysts

IMR OpenIR

	Direct Methylation of Amines with Carbon Dioxide and Molecular Hydrogen using Supported Gold Catalysts
	Du, Xian-Long; Tang, Gao; Bao, Hong-Liang; Jiang, Zheng; Zhong, Xin-Hua; Su, Dang Sheng; Wang, Jian-Qiang; dssu@imr.ac.cn; wangjianqiang@sinap.ac.cn
	2015
发表期刊	CHEMSUSCHEM
ISSN	1864-5631
卷号	8 期号:20 页码:3489-3496
摘要	The N-methylation of amines with CO2 and H-2 is an important step in the synthesis of bioactive compounds and chemical intermediates. The first heterogeneous Au catalyst is reported for this methylation reaction with good to excellent yields. The average turnover frequency (TOF) based on surface Au atoms is 45h(-1), which is the highest TOF value ever reported for the methylation of aniline with CO2 and H-2. Furthermore, the catalyst is tolerant toward a variety of amines, which includes aromatic, aliphatic, secondary, and primary amines. Preliminary mechanistic studies suggest that the N-alkyl formamide might be an intermediate in the N-methylation of amine process. Moreover, through a one-pot process, it is possible to convert primary amines, aldehydes, and CO2 into unsymmetrical tertiary amines with H-2 as a reductant in the presence of the Au catalyst.
部门归属	[du, xian-long ; bao, hong-liang ; jiang, zheng ; wang, jian-qiang] chinese acad sci, shanghai inst appl phys, key lab interfacial phys & technol, shanghai 201800, peoples r china ; [tang, gao ; zhong, xin-hua] e china univ sci & technol, inst appl chem, key lab adv mat, shanghai 200237, peoples r china ; [su, dang sheng] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, peoples r china
关键词	Amines Gold Heterogeneous Catalysis Hydrogen Supported Catalysts
资助者	National Basic Research Program of China [2013CB933104]; Ministry of Science and Technology [2014DFG60230]; National Natural Science Foundation of China [21303246, 11275258, 91127001]; CFI; NSERC; NRC; CIHR; University of Saskatchewan; Government of Saskatchewan; Western Economic Diversification Canada
收录类别	sci
语种	英语
WOS记录号	WOS:000363683000017
引用统计	被引频次：81[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/74722
专题	中国科学院金属研究所
通讯作者	dssu@imr.ac.cn; wangjianqiang@sinap.ac.cn
推荐引用方式 GB/T 7714	Du, Xian-Long,Tang, Gao,Bao, Hong-Liang,et al. Direct Methylation of Amines with Carbon Dioxide and Molecular Hydrogen using Supported Gold Catalysts[J]. CHEMSUSCHEM,2015,8(20):3489-3496.
APA	Du, Xian-Long.,Tang, Gao.,Bao, Hong-Liang.,Jiang, Zheng.,Zhong, Xin-Hua.,...&wangjianqiang@sinap.ac.cn.(2015).Direct Methylation of Amines with Carbon Dioxide and Molecular Hydrogen using Supported Gold Catalysts.CHEMSUSCHEM,8(20),3489-3496.
MLA	Du, Xian-Long,et al."Direct Methylation of Amines with Carbon Dioxide and Molecular Hydrogen using Supported Gold Catalysts".CHEMSUSCHEM 8.20(2015):3489-3496.