Improving the osteointegration of Ti6Al4V by zeolite MFI coating

IMR OpenIR

	Improving the osteointegration of Ti6Al4V by zeolite MFI coating
	Li, Yong; Jiao, Yilai; Li, Xiaokang; Guo, Zheng; guozheng@fmmu.edu.cn
	2015
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	460 期号:2 页码:151-156
摘要	Osteointegration is crucial for success in orthopedic implantation. In recent decades, there have been numerous studies aiming to modify titanium alloys, which are the most widely used materials in orthopedics. Zeolites are solid aluminosilicates whose application in the biomedical field has recently been explored. To this end, MFI zeolites have been developed as titanium alloy coatings and tested in vitro. Nevertheless, the effect of the MFI coating of biomaterials in vivo has not yet been addressed. The aim of the present work is to evaluate the effects of MFI-coated Ti6Al4V implants in vitro and in vivo. After surface modification, the surface was investigated using field emission scanning electron microscopy (FE-SEM) and energy dispersive spectroscopy (EDS). No difference was observed regarding the proliferation of MC3T3-E1 cells on the Ti6Al4V (Ti) and MFI-coated Ti6Al4V (M-Ti) (p > 0.05). However, the attachment of MC3T3-E1 cells was found to be better in the M-Ti group. Additionally, ALP staining and activity assays and quantitative real-time RT-PCR indicated that MC3T3-E1 cells grown on the M-Ti displayed high levels of osteogenic differentiation markers. Moreover, Van-Gieson staining of histological sections demonstrated that the MFI coating on Ti6Al4V scaffolds significantly enhanced osteointegration and promoted bone regeneration after implantation in rabbit femoral condylar defects at 4 and 12 weeks. Therefore, this study provides a method for modifying Ti6Al4V to achieve improved osteointegration and osteogenesis. (C) 2015 Elsevier Inc. All rights reserved.
部门归属	[li, yong ; li, xiaokang ; guo, zheng] fourth mil med univ, dept orthopaed, xijing hosp, xian 710032, shaanxi, peoples r china ; [jiao, yilai] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, liaoning, peoples r china
关键词	Titanium Alloy Surface Modification Zeolites Coating Osteointegration
资助者	Research Fund for the National Natural Science Foundation of China [51271199]; National Natural Science Foundation of China [81171773]; Coordinative and Innovative Engineering Projects of Science and Technology of Shaanxi Province [2012KTCG01-14]
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/74904
专题	中国科学院金属研究所
通讯作者	guozheng@fmmu.edu.cn
推荐引用方式 GB/T 7714	Li, Yong,Jiao, Yilai,Li, Xiaokang,et al. Improving the osteointegration of Ti6Al4V by zeolite MFI coating[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,460(2):151-156.
APA	Li, Yong,Jiao, Yilai,Li, Xiaokang,Guo, Zheng,&guozheng@fmmu.edu.cn.(2015).Improving the osteointegration of Ti6Al4V by zeolite MFI coating.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,460(2),151-156.
MLA	Li, Yong,et al."Improving the osteointegration of Ti6Al4V by zeolite MFI coating".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460.2(2015):151-156.