In vitro study on an antibacterial Ti-5Cu alloy for medical application

IMR OpenIR

	In vitro study on an antibacterial Ti-5Cu alloy for medical application
	Ma, Zheng; Li, Mei; Liu, Rui; Ren, Ling; Zhang, Yu; Pan, Haobo; Zhao, Ying; Yang, Ke; ying.zhao@siat.ac.cn; kyang@imr.ac.cn
	2016
发表期刊	JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
ISSN	0957-4530
卷号	27 期号:5 页码:-
摘要	Health of human beings is subjected to severe threats from the spread of harmful bacteria and the implant-associated infection remains a serious problem in clinic. In this study, a copper-bearing antibacterial titanium alloy, Ti-5Cu, has been developed for dental and orthopedic implant applications. The microstructure, mechanical property, electrochemical corrosion behavior, in vitro antibacterial performance, cytocompatibility and hemocompatibility of the alloy are systematically investigated. The results reveal that the Ti-5Cu alloy which consists of a-phase matrix and intermetallic compound Ti2Cu not only possesses strong antibacterial activity against both E. coli and S. aureus, but also exhibits better mechanical properties than the commercial pure titanium. It is confirmed that the release of trace amount of Cu ions from the alloy plays an important role in killing bacteria. In spite of the ion release, Ti-5Cu alloy still reveals excellent corrosion resistance. Moreover, good cytocompatibility and superior hemocompatibility make Ti-5Cu alloy to be a potential solution that could prevent the peri-implant infection in dental and orthopaedic applications.
部门归属	[ma, zheng ; pan, haobo ; zhao, ying] chinese acad sci, shenzhen inst adv technol, ctr human tissues & organs degenerat, shenzhen, peoples r china ; [ma, zheng ; liu, rui ; ren, ling ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china ; [li, mei ; zhang, yu] guangzhou mil gen hosp, dept orthoped, guangzhou, guangdong, peoples r china
资助者	National Basic Research Program of China [2012 CB619101]; National Natural Science Foundation of China [81 271957, 51501218, 81572113]; Guangdong Provincial Science and technology Projects [2014A010105033]; Shenzhen Peacock Programs [KQCX20140521115045444, 110811003586331]; Basic Research Project of Shenzhen City [JCYJ20120616142847342]
收录类别	sci
语种	英语
WOS记录号	WOS:000372261300010
引用统计	被引频次：47[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/74911
专题	中国科学院金属研究所
通讯作者	ying.zhao@siat.ac.cn; kyang@imr.ac.cn
推荐引用方式 GB/T 7714	Ma, Zheng,Li, Mei,Liu, Rui,et al. In vitro study on an antibacterial Ti-5Cu alloy for medical application[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2016,27(5):-.
APA	Ma, Zheng.,Li, Mei.,Liu, Rui.,Ren, Ling.,Zhang, Yu.,...&kyang@imr.ac.cn.(2016).In vitro study on an antibacterial Ti-5Cu alloy for medical application.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,27(5),-.
MLA	Ma, Zheng,et al."In vitro study on an antibacterial Ti-5Cu alloy for medical application".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 27.5(2016):-.