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Monodisperse water-soluble gamma-Fe2O3/polyvinylpyrrolidone nanoparticles for a magnetic resonance imaging contrast agent
Li, D.; Li, S. J.; Zhang, Y.; Jiang, J. J.; Gong, W. J.; Wang, J. H.; Zhang, Z. D.; dali@imr.ac.cn
2015
发表期刊MATERIALS RESEARCH INNOVATIONS
ISSN1432-8917
卷号19页码:S358-S362
摘要Water-soluble gamma-Fe2O3/polyvinylpyrrolidone (PVP) nanoparticles were obtained by transferring oleic acid (OA) coated iron-oxide nanocrystals from hexane to water. The particle size of the gamma-Fe2O3/PVP nanoparticles with excellent monodispersity is about 14 nm. Fourier transform-infrared (FT-IR) spectroscopy and X-ray photoelectron spectroscopy (XPS) results indicate that PVP anchors on the gamma-Fe2O3 nanoparticles through its carbonyl group and provided sufficient hydrophilicity. The maghemite content in the gamma-Fe2O3/PVP nanoparticles was about 81 wt-%. The saturation magnetisation of the superparamagnetic gamma-Fe2O3/PVP nanoparticles is 57.7 emu g(-1) at 295 K. For in vivo magnetic resonance imaging (MRI) studies, the gamma-Fe2O3/PVP nanoparticles can be guided to the target area by a permanent magnet and show negative contrast enhancement on the target area of laboratory mice.
部门归属[li, d. ; li, s. j. ; jiang, j. j. ; gong, w. j. ; wang, j. h. ; zhang, z. d.] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, peoples r china ; [zhang, y.] shenyang pharmaceut univ, coll pharmaceut engn, shenyang 110016, peoples r china
关键词Superparamagnetism Nanoparticles Magnetic Resonance Imaging Contrast Agent
资助者National Natural Science Foundation of China [51171185]; Liaoning Province [20111136]
收录类别sci
语种英语
文献类型期刊论文
条目标识符http://ir.imr.ac.cn/handle/321006/75005
专题中国科学院金属研究所
通讯作者dali@imr.ac.cn
推荐引用方式
GB/T 7714
Li, D.,Li, S. J.,Zhang, Y.,et al. Monodisperse water-soluble gamma-Fe2O3/polyvinylpyrrolidone nanoparticles for a magnetic resonance imaging contrast agent[J]. MATERIALS RESEARCH INNOVATIONS,2015,19:S358-S362.
APA Li, D..,Li, S. J..,Zhang, Y..,Jiang, J. J..,Gong, W. J..,...&dali@imr.ac.cn.(2015).Monodisperse water-soluble gamma-Fe2O3/polyvinylpyrrolidone nanoparticles for a magnetic resonance imaging contrast agent.MATERIALS RESEARCH INNOVATIONS,19,S358-S362.
MLA Li, D.,et al."Monodisperse water-soluble gamma-Fe2O3/polyvinylpyrrolidone nanoparticles for a magnetic resonance imaging contrast agent".MATERIALS RESEARCH INNOVATIONS 19(2015):S358-S362.
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