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Osteogenic ability of Cu-bearing stainless steel
Ren, Ling; Wong, Hoi Man; Yan, Chun Hoi; Yeung, Kelvin W. K.; Yang, Ke; kyang@imr.ac.cn
2015
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
ISSN1552-4973
Volume103Issue:7Pages:1433-1444
AbstractA newly developed copper-bearing stainless steel (Cu-SS) by directly immobilizing proper amount of Cu into a medical stainless steel (317L SS) during the metallurgical process could enable continuous release of trace amount of Cu2+ ions, which play the key role to offer the multibiofunctions of the stainless steel, including the osteogenic ability in the present study. The results of in vitro experiments clearly demonstrated that Cu2+ ions from Cu-SS could promote the osteogenic differentiation by stimulating the Alkaline phosphatase enzyme activity and the osteogenic gene expressions (Col1a1, Opn, and Runx2), and enhancing the adhesion and proliferation of osteoblasts cultured on its surface. The in vivo test further proved that more new bone tissue formed around the Cu-SS implant with more stable bone-to-implant contact in comparison with the 317L SS. In addition, Cu-SS showed satisfied bio- compatibility according to the results of in vitro cytotoxicity and in vivo histocompatibility, and its daily released amount of Cu2- ions in physiological saline solution was at trace level of ppb order (1.4 ppb/cm(2)), which is rather safe to human health. Apart from these results, it was also found that Cu-SS could inhibit the happening of inflammation with lower TNF-(x expression in the bone tissue post implantation compared with 317L SS. In addition to good biocompatibility, the overall findings demonstrated that the Cu-SS possessed obvious ability of promoting osteogenesis, indicating a unique application advantage in orthopedics. (C) 2014 Wiley Periodicals, Inc. J Blamed Mater Res Part B: Appl Biomater, 103B: 1433-1444,2015.
description.department[ren, ling] chinese acad sci, inst met res, shenyang 110016, peoples r china ; [wong, hoi man ; yan, chun hoi ; yeung, kelvin w. k. ; yang, ke] univ hong kong, dept orthopaed & traumatol, pokfulam, hong kong, peoples r china ; [wong, hoi man ; yan, chun hoi ; yeung, kelvin w. k.] univ hong kong, shenzhen hosp, shenzhen key lab innovat technol orthopaed trauma, shenzhen, peoples r china
KeywordStainless Steel Metal Ions Bone Osteogenesis Bioactive Material
Funding OrganizationNational Basic Research Program of China (973 Program) [2012CB619101]; National Natural Science Foundation of China [81301329]; Shenyang National Lab for Materials Science
Indexed Bysci
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/75043
Collection中国科学院金属研究所
Corresponding Authorkyang@imr.ac.cn
Recommended Citation
GB/T 7714
Ren, Ling,Wong, Hoi Man,Yan, Chun Hoi,et al. Osteogenic ability of Cu-bearing stainless steel[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2015,103(7):1433-1444.
APA Ren, Ling,Wong, Hoi Man,Yan, Chun Hoi,Yeung, Kelvin W. K.,Yang, Ke,&kyang@imr.ac.cn.(2015).Osteogenic ability of Cu-bearing stainless steel.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,103(7),1433-1444.
MLA Ren, Ling,et al."Osteogenic ability of Cu-bearing stainless steel".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 103.7(2015):1433-1444.
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