Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting

IMR OpenIR

	Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting
	Huang, Hai; Lan, Ping-Heng; Zhang, Yong-Quan; Li, Xiao-Kang; Zhang, Xing; Yuan, Chao-Fan; Zheng, Xue-Bin; Guo, Zheng; guozheng@fmmu.edu.cn
	2015
发表期刊	SURFACE & COATINGS TECHNOLOGY
ISSN	0257-8972
卷号	283 页码:80-88
摘要	Porous titanium with high strength and a low elastic modulus has received attention as an excellent orthopedic implant; however, the fabrication and biological performance of porous implant both need to be improved. A porous Ti6Al4V implant (11) was prepared using the electron beam melting method, and some samples underwent surface modification with a hydroxyapatite coating (HA-TI) by plasma-spraying. After characterization of their surfaces, the TI and HA-TI materials were implanted into distal femur bone defects of sheep, and bone formation and osteointegration were evaluated at 2 and 4 months post-implantation. A micro computed tomography analysis indicated that the porous Ti6Al4V implant with interconnected pores had a high porosity similar to 69 +/- 5% and large pore size similar to 514 +/- 35 mu m. Scanning electron microscopy, energy dispersive spectrometry, and X-ray diffraction analyses revealed that the HA coating was successfully deposited on the exterior surface of the implants; the elemental composition of the internal surface of the HA-TI material included calcium and phosphorus, as well as titanium and aluminum. Confocal laser scanning microscopy revealed that the surface roughness of the HA-TI group was significantly higher than that of the TI group. Micro computed tomography and histological analyses indicated that the bone formation of the HA-TI group was superior to that of the TI group at both 2 and 4 months post-implantation. In the HA-TI group, the new bone contacted the coating of the implant directly, and no fibrous tissue or gaps were observed at the bone-implant interface. This study demonstrates that hydroxyapatite coating of porous Ti6Al4V implants by plasma-spraying is suitable to improve the bone formation and osteointegration capabilities. In addition, the results demonstrate that HA-coated porous Ti6Al4V implants generated by electron beam melting have excellent prospects in orthopedic applications. (C) 2015 Elsevier B.V. All rights reserved.
部门归属	[huang, hai ; lan, ping-heng ; zhang, yong-quan ; li, xiao-kang ; yuan, chao-fan ; guo, zheng] fourth mil med univ, xijing hosp, dept orthoped, xian 710032, shaanxi, peoples r china ; [zhang, xing] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, liaoning, peoples r china ; [zheng, xue-bin] chinese acad sci, key lab inorgan coating mat, shanghai, peoples r china
关键词	Porous Titanium Electron Beam Melting Bone Ingrowth Hydroxyapatite Osteointegration Surface Treatment
资助者	National Natural Science Foundation of China [51271199, 81171773]; National High Technology Research and Development Program ("863" Program) of China [2015AA033702]
收录类别	sci
语种	英语
WOS记录号	WOS:000368557300010
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/75153
专题	中国科学院金属研究所
通讯作者	guozheng@fmmu.edu.cn
推荐引用方式 GB/T 7714	Huang, Hai,Lan, Ping-Heng,Zhang, Yong-Quan,et al. Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting[J]. SURFACE & COATINGS TECHNOLOGY,2015,283:80-88.
APA	Huang, Hai.,Lan, Ping-Heng.,Zhang, Yong-Quan.,Li, Xiao-Kang.,Zhang, Xing.,...&guozheng@fmmu.edu.cn.(2015).Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting.SURFACE & COATINGS TECHNOLOGY,283,80-88.
MLA	Huang, Hai,et al."Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting".SURFACE & COATINGS TECHNOLOGY 283(2015):80-88.