|Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application|
|Han, Junjie; Wan, Peng; Ge, Ye; Fan, Xinmin; Tan, Lili; Li, Jianjun; Yang, Ke; email@example.com; firstname.lastname@example.org
|发表期刊||MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
|摘要||Bone defects are very challenging in orthopedic practice. There are many practical and clinical shortcomings in the repair of the defect by using autografts, allografts or xenografts, which continue to motivate the search for better alternatives. The ideal bone grafts should provide mechanical support, fill osseous voids and enhance the bone healing. Biodegradable magnesium-strontium (Mg-Sr) alloys demonstrate good biocompatibility and osteoconductive properties, which are promising biomaterials for bone substitutes. The aim of this study was to evaluate and pair the degradation of Mg-Sr alloys for grafting with their clinical demands. The microstructure and performance of Mg-Sr alloys, in vitro degradation and biological properties including in vitro cytocompatibility and in vivo implantation were investigated. The results showed that the as-cast Mg-Sr alloy exhibited a rapid degradation rate compared with the as-extruded alloy due to the intergranular distribution of the second phase and micro-galvanic corrosion. However, the initial degradation could be tailored by the coating protection, which was proved to be cytocompatible and also suitable for bone repair observed by in vivo implantation. The integrated fracture calluses were formed and bridged the fracture gap without gas bubble accumulation, meanwhile the substitutes simultaneously degraded. In conclusion, the as-cast Mg-Sr alloy with coating is potential to be used for bone substitute alternative. (C) 2015 Elsevier B.V. All rights reserved.|
; fan, xinmin] nanjing univ sci & technol, dept mat sci & engn, nanjing 210094, jiangsu, peoples r china
; [han, junjie
; wan, peng
; tan, lili
; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china
; [ge, ye
; li, jianjun] china med univ, shengjing hosp, shenyang 100004, peoples r china
|资助者||National High Technology Research and Development Program of China (863 Program) [2015AA033701]; Chinese Academy of Sciences-Croucher Founding Scheme for Joint Laboratories [CAS 14303]
Han, Junjie,Wan, Peng,Ge, Ye,et al. Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2016,58:799-811.
Han, Junjie.,Wan, Peng.,Ge, Ye.,Fan, Xinmin.,Tan, Lili.,...&email@example.com.(2016).Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,58,799-811.
Han, Junjie,et al."Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 58(2016):799-811.