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Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects
Liu, Chen; Fu, Xuekun; Pan, Haobo; Wan, Peng; Wang, Lei; Tan, Lili; Wang, Kehong; Zhao, Ying; Yang, Ke; Chu, Paul K.; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.; Zhao, Y (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China.
2016-06-07
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6
AbstractA series of biodegradable Mg-Cu alloys is designed to induce osteogenesis, stimulate angiogenesis, and provide long-lasting antibacterial performance at the same time. The Mg-Cu alloys with precipitated Mg2Cu intermetallic phases exhibit accelerated degradation in the physiological environment due to galvanic corrosion and the alkaline environment combined with Cu release endows the Mg-Cu alloys with prolonged antibacterial effects. In addition to no cytotoxicity towards HUVECs and MC3T3-E1 cells, the Mg-Cu alloys, particularly Mg-0.03Cu, enhance the cell viability, alkaline phosphatase activity, matrix mineralization, collagen secretion, osteogenesis-related gene and protein expressions of MC3T3-E1 cells, cell proliferation, migration, endothelial tubule forming, angiogenesis-related gene, and protein expressions of HUVECs compared to pure Mg. The favorable osteogenesis and angiogenesis are believed to arise from the release of bioactive Mg and Cu ions into the biological environment and the biodegradable Mg-Cu alloys with osteogenesis, angiogenesis, and long-term antibacterial ability are very promising in orthopedic applications.
description.department[liu, chen ; wan, peng ; tan, lili ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china ; [liu, chen ; wang, kehong] nanjing univ sci & technol, dept mat sci & engn, nanjing, jiangsu, peoples r china ; [liu, chen ; fu, xuekun ; pan, haobo ; wang, lei ; zhao, ying] chinese acad sci, shenzhen inst adv technol, shenzhen, peoples r china ; [chu, paul k.] city univ hong kong, dept phys & mat sci, tat chee ave, hong kong, hong kong, peoples r china
Subject AreaScience & Technology - Other Topics
Funding OrganizationNational Basic Research Program of China [2012CB619101]; National High Technology Research and Development Program of China [2015AA033701]; National Natural Science Foundation of China [81572113, 51501218, 31500777, 81401773]; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Guangdong Provincial Science and technology projects [2014A010105033]; Shenzhen Peacock Programs [KQCX20140521115045444, 110811003586331]; Shenzhen-Hong Kong Technology Cooperation Funding Scheme [SGLH20150213143207919]; Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [112212]; City University of Hong Kong Strategy Research Grant (SRG) [7004188]
Indexed Bysci
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/75834
Collection中国科学院金属研究所
Corresponding AuthorYang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.; Zhao, Y (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China.
Recommended Citation
GB/T 7714
Liu, Chen,Fu, Xuekun,Pan, Haobo,et al. Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects[J]. SCIENTIFIC REPORTS,2016,6.
APA Liu, Chen.,Fu, Xuekun.,Pan, Haobo.,Wan, Peng.,Wang, Lei.,...&Zhao, Y .(2016).Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects.SCIENTIFIC REPORTS,6.
MLA Liu, Chen,et al."Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects".SCIENTIFIC REPORTS 6(2016).
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