Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects

IMR OpenIR

	Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects
	Liu, Chen; Fu, Xuekun; Pan, Haobo; Wan, Peng; Wang, Lei; Tan, Lili; Wang, Kehong; Zhao, Ying; Yang, Ke; Chu, Paul K.; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.; Zhao, Y (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China.
	2016-06-07
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	6
摘要	A series of biodegradable Mg-Cu alloys is designed to induce osteogenesis, stimulate angiogenesis, and provide long-lasting antibacterial performance at the same time. The Mg-Cu alloys with precipitated Mg2Cu intermetallic phases exhibit accelerated degradation in the physiological environment due to galvanic corrosion and the alkaline environment combined with Cu release endows the Mg-Cu alloys with prolonged antibacterial effects. In addition to no cytotoxicity towards HUVECs and MC3T3-E1 cells, the Mg-Cu alloys, particularly Mg-0.03Cu, enhance the cell viability, alkaline phosphatase activity, matrix mineralization, collagen secretion, osteogenesis-related gene and protein expressions of MC3T3-E1 cells, cell proliferation, migration, endothelial tubule forming, angiogenesis-related gene, and protein expressions of HUVECs compared to pure Mg. The favorable osteogenesis and angiogenesis are believed to arise from the release of bioactive Mg and Cu ions into the biological environment and the biodegradable Mg-Cu alloys with osteogenesis, angiogenesis, and long-term antibacterial ability are very promising in orthopedic applications.
部门归属	[liu, chen ; wan, peng ; tan, lili ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china ; [liu, chen ; wang, kehong] nanjing univ sci & technol, dept mat sci & engn, nanjing, jiangsu, peoples r china ; [liu, chen ; fu, xuekun ; pan, haobo ; wang, lei ; zhao, ying] chinese acad sci, shenzhen inst adv technol, shenzhen, peoples r china ; [chu, paul k.] city univ hong kong, dept phys & mat sci, tat chee ave, hong kong, hong kong, peoples r china
学科领域	Science & Technology - Other Topics
资助者	National Basic Research Program of China [2012CB619101]; National High Technology Research and Development Program of China [2015AA033701]; National Natural Science Foundation of China [81572113, 51501218, 31500777, 81401773]; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Guangdong Provincial Science and technology projects [2014A010105033]; Shenzhen Peacock Programs [KQCX20140521115045444, 110811003586331]; Shenzhen-Hong Kong Technology Cooperation Funding Scheme [SGLH20150213143207919]; Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [112212]; City University of Hong Kong Strategy Research Grant (SRG) [7004188]
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/75834
专题	中国科学院金属研究所
通讯作者	Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.; Zhao, Y (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China.
推荐引用方式 GB/T 7714	Liu, Chen,Fu, Xuekun,Pan, Haobo,et al. Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects[J]. SCIENTIFIC REPORTS,2016,6.
APA	Liu, Chen.,Fu, Xuekun.,Pan, Haobo.,Wan, Peng.,Wang, Lei.,...&Zhao, Y .(2016).Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects.SCIENTIFIC REPORTS,6.
MLA	Liu, Chen,et al."Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects".SCIENTIFIC REPORTS 6(2016).