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The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model
Sun, Wei; Zhang, Guangdao; Tan, Lili; Yang, Ke; Ai, Hongjun; Ai, HJ (reprint author), China Med Univ, Sch Stomatol, Dept Prosthodont, 117 North Nanjing St, Shenyang 110001, Peoples R China.
2016-06-01
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume63Pages:506-511
AbstractThis study aimed to evaluate the effect of fluorine coated Mg alloy and clarify its mechanism in bone formation. We implanted the fluorine coated AZ31B Mg alloy screw (group F) in rabbit mandibular and femur in vivo. Untreated AZ31B Mg alloy screw (group A) and titanium screw (group T) were used as control. Then, scanning electron microscopy, the spectral energy distribution analysis, hard and decalcified bone tissues staining were performed. Immunohistochemistry was employed to examine the protein expressions of bone morphogenetic protein 2 (BMP-2) and collagen type I in the vicinity of the implant. Compared with the group A, the degradation of the alloy was reduced, the rates of Mg corrosion and Mg ion release were slowed down, and the depositions of calcium and phosphate increased in the group F in the early stage of implantation. Histological results showed that fluorine coated Mg alloy had well osteogenic activity and biocompatibility. Moreover, fluoride coating obviously up-regulated the expressions of collagen type I and BMP-2. This study confirmed that the fluorine coating might improve the corrosion resistance of AZ31B Mg alloy and promote bone formation by up-regulated the expressions of collagen type I and BMP-2. (C) 2016 Elsevier B.V. All rights reserved.
description.department[sun, wei ; zhang, guangdao ; ai, hongjun] china med univ, sch stomatol, dept prosthodont, 117 north nanjing st, shenyang 110001, peoples r china ; [tan, lili ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china
KeywordFluorine Coated Az31b Magnesium Alloy Osteogenic Activity Corrosion Resistance Bone Morphogenetic Protein 2 Collagen Type i
Subject AreaMaterials Science
Funding OrganizationShenyang Science and Technology Project [F15-139-9-38]
Indexed Bysci
Language英语
WOS IDWOS:000374916800057
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/75866
Collection中国科学院金属研究所
Corresponding AuthorAi, HJ (reprint author), China Med Univ, Sch Stomatol, Dept Prosthodont, 117 North Nanjing St, Shenyang 110001, Peoples R China.
Recommended Citation
GB/T 7714
Sun, Wei,Zhang, Guangdao,Tan, Lili,et al. The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2016,63:506-511.
APA Sun, Wei,Zhang, Guangdao,Tan, Lili,Yang, Ke,Ai, Hongjun,&Ai, HJ .(2016).The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,63,506-511.
MLA Sun, Wei,et al."The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 63(2016):506-511.
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