IMR OpenIR
The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model
Sun, Wei; Zhang, Guangdao; Tan, Lili; Yang, Ke; Ai, Hongjun; Ai, HJ (reprint author), China Med Univ, Sch Stomatol, Dept Prosthodont, 117 North Nanjing St, Shenyang 110001, Peoples R China.
2016-06-01
发表期刊MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
卷号63页码:506-511
摘要This study aimed to evaluate the effect of fluorine coated Mg alloy and clarify its mechanism in bone formation. We implanted the fluorine coated AZ31B Mg alloy screw (group F) in rabbit mandibular and femur in vivo. Untreated AZ31B Mg alloy screw (group A) and titanium screw (group T) were used as control. Then, scanning electron microscopy, the spectral energy distribution analysis, hard and decalcified bone tissues staining were performed. Immunohistochemistry was employed to examine the protein expressions of bone morphogenetic protein 2 (BMP-2) and collagen type I in the vicinity of the implant. Compared with the group A, the degradation of the alloy was reduced, the rates of Mg corrosion and Mg ion release were slowed down, and the depositions of calcium and phosphate increased in the group F in the early stage of implantation. Histological results showed that fluorine coated Mg alloy had well osteogenic activity and biocompatibility. Moreover, fluoride coating obviously up-regulated the expressions of collagen type I and BMP-2. This study confirmed that the fluorine coating might improve the corrosion resistance of AZ31B Mg alloy and promote bone formation by up-regulated the expressions of collagen type I and BMP-2. (C) 2016 Elsevier B.V. All rights reserved.
部门归属[sun, wei ; zhang, guangdao ; ai, hongjun] china med univ, sch stomatol, dept prosthodont, 117 north nanjing st, shenyang 110001, peoples r china ; [tan, lili ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china
关键词Fluorine Coated Az31b Magnesium Alloy Osteogenic Activity Corrosion Resistance Bone Morphogenetic Protein 2 Collagen Type i
学科领域Materials Science
资助者Shenyang Science and Technology Project [F15-139-9-38]
收录类别sci
语种英语
文献类型期刊论文
条目标识符http://ir.imr.ac.cn/handle/321006/75866
专题中国科学院金属研究所
通讯作者Ai, HJ (reprint author), China Med Univ, Sch Stomatol, Dept Prosthodont, 117 North Nanjing St, Shenyang 110001, Peoples R China.
推荐引用方式
GB/T 7714
Sun, Wei,Zhang, Guangdao,Tan, Lili,et al. The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2016,63:506-511.
APA Sun, Wei,Zhang, Guangdao,Tan, Lili,Yang, Ke,Ai, Hongjun,&Ai, HJ .(2016).The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,63,506-511.
MLA Sun, Wei,et al."The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 63(2016):506-511.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Sun, Wei]的文章
[Zhang, Guangdao]的文章
[Tan, Lili]的文章
百度学术
百度学术中相似的文章
[Sun, Wei]的文章
[Zhang, Guangdao]的文章
[Tan, Lili]的文章
必应学术
必应学术中相似的文章
[Sun, Wei]的文章
[Zhang, Guangdao]的文章
[Tan, Lili]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。