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Biodegradable Mg-Cu alloy implants with antibacterial activity for the treatment of osteomyelitis: In vitro and in vivo evaluations
Li, Y; Liu, LN; Wan, P; Zhai, ZJ; Mao, ZY; Ouyang, ZX; Yu, DG; Sun, Q; Tan, LL; Ren, L; Zhu, ZA; Hao, YQ; Qu, XH; Yang, K; Dai, KR; Dai, KR (reprint author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Shanghai Key Lab Orthopaed Implants,Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.
2016-11-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume106Pages:250-263
AbstractTreatment of chronic osteomyelitis (bone infection) remains a clinical challenge; in particular, it requires an implantable material with improved antibacterial activity. Here, we prepared biodegradable magnesium (Mg)-copper (Cu) alloys with different Cu contents (0.05, 0.1, and 0.25 wt%) and assessed their potential for treating methicillin-resistant Staphylococcus aureus-induced osteomyelitis. We evaluated the microstructures, mechanical properties, corrosion behavior, and ion release of the alloys in vitro, and their biocompatibility and antibacterial activity in vitro and in vivo. The antibacterial activity of the Mg Cu alloys in vitro was demonstrated by microbiological counting assays, bacterial viability assays, biofilm formation observations, and the expression of biofilm, virulence, and antibiotic-resistance associated genes. The antibacterial activity of Mg-Cu alloys in vivo was confirmed by imaging examination, microbiological cultures, and histopathology. The biocompatibility of Mg-Cu alloys was confirmed by cell proliferation, vitality, and morphology assays in vitro and Cu2+ or Mg2+ ion assays, blood biochemical tests, and histological evaluation in vivo. The alloy containing 0.25 wt% Cu exhibited the highest antibacterial activity among the tested alloys, with favorable biocompatibility. Collectively, our results indicate the potential utility of Mg -Cu alloy implants with 0.25 wt% Cu in treating orthopedic infections. (C) 2016 Elsevier Ltd. All rights reserved.
description.department[li, yang ; zhai, zanjing ; mao, zhenyang ; ouyang, zhengxiao ; yu, degang ; zhu, zhenan ; hao, yongqiang ; qu, xinhua ; dai, kerong] shanghai jiao tong univ, shanghai peoples hosp 9, dept orthopaed surg, shanghai key lab orthopaed implants,sch med, 639 zhizaoju rd, shanghai 200011, peoples r china ; [liu, lina] shanghai jiao tong univ, shanghai peoples hosp 9, dept plast & reconstruct surg, sch med, shanghai, peoples r china ; [wan, peng ; tan, lili ; ren, ling ; yang, ke] chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china ; [sun, qi] shanghai jiao tong univ, sch med, shanghai peoples hosp 9, dept radiol, shanghai, peoples r china
KeywordOsteomyelitis Antibacterial Activity Biodegradable Mg-cu Alloy
Subject AreaEngineering, Biomedical ; Materials Science, bioMaterials
Funding OrganizationKey National Basic Research Program of China [2012CB619101, 2015AA033603]; National Natural Science Foundation of China [81190133]; National Natural Science Foundation for Youths [81401852, 81401773, 31500777]; Doctoral Innovation Fund Projects from Shanghai Jiao Tong University's School of Medicine [BXJ201430]; Natural Science Foundation of Shanghai [14ZR1424000]; "Chen Guang" Project of the Shanghai Municipal Education Commission; Shanghai Education Development Foundation [14CG14]
Indexed Bysci
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/76216
Collection中国科学院金属研究所
Corresponding AuthorQu, XH; Dai, KR (reprint author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Shanghai Key Lab Orthopaed Implants,Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.
Recommended Citation
GB/T 7714
Li, Y,Liu, LN,Wan, P,et al. Biodegradable Mg-Cu alloy implants with antibacterial activity for the treatment of osteomyelitis: In vitro and in vivo evaluations[J]. BIOMATERIALS,2016,106:250-263.
APA Li, Y.,Liu, LN.,Wan, P.,Zhai, ZJ.,Mao, ZY.,...&Yang, K .(2016).Biodegradable Mg-Cu alloy implants with antibacterial activity for the treatment of osteomyelitis: In vitro and in vivo evaluations.BIOMATERIALS,106,250-263.
MLA Li, Y,et al."Biodegradable Mg-Cu alloy implants with antibacterial activity for the treatment of osteomyelitis: In vitro and in vivo evaluations".BIOMATERIALS 106(2016):250-263.
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